MRP-S14 Activators
MRP-S14, also recognized by its alternative nomenclature S100A11, is part of the multifaceted S100 protein family known for their roles in intracellular and extracellular regulatory activities. Characterized by their two distinct calcium-binding EF-hand motifs, these proteins are integral to a broad spectrum of biological processes, including but not limited to the regulation of protein phosphorylation, modulation of cytoskeletal components, and involvement in cellular growth and differentiation mechanisms. MRP-S14 in particular has garnered attention for its expression patterns which are responsive to various environmental and cellular stimuli. The protein has been observed to have a heightened expression in response to specific physiological stressors, suggesting a potential role in the cellular stress response. The expression of MRP-S14 is not uniform and can vary significantly depending on cellular context, indicating a complex regulatory network that governs its activity.
Within this intricate network, certain chemical compounds have been identified as potential activators of MRP-S14 expression, each exerting its influence through distinct biochemical pathways. These activators range from elements and compounds that are known to induce oxidative stress, such as hydrogen peroxide, to heavy metals like cadmium chloride and lead(II) acetate, which may provoke a cellular defense mechanism leading to increased expression of MRP-S14. Organic compounds like bisphenol A and benzo(a)pyrene, associated with environmental exposure, could also play a role in the upregulation of MRP-S14, possibly as part of the cellular adaptation to xenobiotic stress. Other compounds like lithium chloride and thapsigargin may stimulate MRP-S14 expression through their effects on signal transduction and calcium homeostasis, respectively. Collectively, these chemical activators highlight the sensitivity of MRP-S14 to a diverse array of signals, reflecting the protein's potential involvement in responding to cellular alterations and environmental challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can upregulate MRP-S14 expression by promoting cellular differentiation and growth, particularly in skin and immune cells. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
This hormonally active form of vitamin D can stimulate MRP-S14 expression by enhancing calcium absorption and influencing cell proliferation in bone and immune cells. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
As an inducer of oxidative stress, hydrogen peroxide can trigger an increase in MRP-S14 expression as part of the antioxidative defense mechanism in various cell types. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Lead exposure can stimulate MRP-S14 expression through the activation of stress response pathways and alteration of cellular defense mechanisms. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium exposure can lead to a pronounced increase in MRP-S14 expression by causing cellular stress and triggering detoxification pathways. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic compounds can stimulate MRP-S14 expression due to their ability to generate oxidative stress and prompt an inflammatory response. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could upregulate MRP-S14 expression by exerting anti-inflammatory effects and influencing stress-related metabolic pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may induce MRP-S14 expression through its action on signal transduction pathways that influence cell survival and neuroprotection. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin can increase MRP-S14 expression by perturbing calcium storage and activating stress-induced signaling cascades. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A might stimulate MRP-S14 expression by acting as an endocrine disruptor and altering gene expression related to growth and development. | ||||||