MRGG Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, leading to increased cAMP production via adenylate cyclase activation. This elevation in cAMP can lead to the activation of PKA, which could phosphorylate and activate MRGG. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G-protein-coupled receptors (GPCRs), which can lead to an increase in intracellular cAMP levels. The raised cAMP levels can activate PKA, which in turn may phosphorylate and activate MRGG. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may then phosphorylate and activate proteins within its pathway, including MRGG. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, which leads to an increase in cAMP levels by preventing its degradation. Higher cAMP can activate PKA, potentially leading to the phosphorylation and activation of MRGG. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs). These kinases may phosphorylate a range of substrates, potentially including MRGG as part of the cellular stress response. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
12-O-Tetradecanoylphorbol-13-acetate (TPA) activates protein kinase C (PKC), which can phosphorylate a variety of intracellular targets. PKC-mediated phosphorylation of targets within the signaling pathways could lead to the activation of MRGG. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which increases cAMP levels in the cell by preventing its breakdown. The elevated cAMP levels may lead to activation of PKA, which could phosphorylate and activate MRGG. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5 (PDE5), leading to increased cGMP levels, which can activate PKG. PKG activation may result in phosphorylation events within its pathway that activate MRGG. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide is a selective inhibitor of phosphodiesterase 3 (PDE3), which leads to an increase in cAMP levels in the cell. Elevated cAMP can activate PKA, which may lead to the phosphorylation and subsequent activation of MRGG. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $33.00 $124.00 $218.00 $947.00 | 9 | |
YC-1 is a soluble guanylyl cyclase (sGC) activator, which increases cGMP levels within cells. The increase in cGMP may activate PKG, which could phosphorylate and activate MRGG within its signaling pathway. | ||||||