Date published: 2026-4-24

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MRCL3 Inhibitors

MRCL3 inhibitors, also known as MRCL3 (Methyltransferase like 3) inhibitors, belong to a class of small molecules that have gained significant attention in the field of molecular biology and cellular research. These compounds are designed to target and modulate the activity of MRCL3, a specific methyltransferase enzyme, which plays a crucial role in epigenetic regulation and gene expression control. MRCL3 is a member of the methyltransferase family, and its primary function is to catalyze the transfer of methyl groups from donor molecules to specific histone proteins or DNA sequences, thus altering the epigenetic landscape of cells.

The inhibition of MRCL3 by these chemical compounds has been explored as a means to investigate the intricate mechanisms of epigenetic regulation within cells. By disrupting MRCL3 activity, researchers can study the downstream effects on gene expression patterns, chromatin structure, and ultimately, cellular function. This class of inhibitors typically works by binding to the active site of MRCL3, impeding its enzymatic function and subsequently leading to changes in the epigenetic marks on chromatin. This allows scientists to gain insights into how epigenetic modifications impact various cellular processes and identify novel pathways for intervention in the future. MRCL3 inhibitors have become valuable tools in deciphering the complexities of epigenetics and advancing our understanding of gene regulation mechanisms.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

N-Ethylmaleimide

128-53-0sc-202719A
sc-202719
sc-202719B
sc-202719C
sc-202719D
1 g
5 g
25 g
100 g
250 g
$22.00
$69.00
$214.00
$796.00
$1918.00
19
(1)

N-ethylmaleimide is an alkylating agent that covalently modifies cysteine residues in proteins, potentially disrupting the function of MRCL3 through thiol modification.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG-132 is a proteasome inhibitor that can block the degradation of MRCL3, leading to its accumulation and potential inhibition of its target proteins.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Brefeldin A disrupts vesicular trafficking and Golgi apparatus function, possibly affecting MRCL3's role in regulating membrane protein trafficking.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Chloroquine inhibits lysosomal function, which may interfere with MRCL3's role in targeting proteins for degradation via the lysosome.

Z-VAD-FMK

187389-52-2sc-3067
500 µg
$75.00
256
(6)

Z-VAD-FMK is a broad-spectrum caspase inhibitor that may prevent caspase-mediated cleavage of MRCL3 or its target proteins.

Leupeptin hemisulfate

103476-89-7sc-295358
sc-295358A
sc-295358D
sc-295358E
sc-295358B
sc-295358C
5 mg
25 mg
50 mg
100 mg
500 mg
10 mg
$73.00
$148.00
$316.00
$499.00
$1427.00
$101.00
19
(3)

Leupeptin is a protease inhibitor that could interfere with MRCL3-mediated protein degradation by inhibiting lysosomal proteases.

Puromycin dihydrochloride

58-58-2sc-108071
sc-108071B
sc-108071C
sc-108071A
25 mg
250 mg
1 g
50 mg
$42.00
$214.00
$832.00
$66.00
394
(16)

Puromycin is an aminonucleoside antibiotic that can disrupt protein synthesis, potentially affecting the substrates processed by MRCL3.

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
$114.00
$203.00
$354.00
$697.00
$1363.00
$5836.00
12
(1)

Eeyarestatin I disrupts endoplasmic reticulum (ER) function and may impact MRCL3's role in ER-associated protein degradation (ERAD).

Pyrrolidinedithiocarbamic acid ammonium salt

5108-96-3sc-203224
sc-203224A
5 g
25 g
$33.00
$64.00
11
(1)

Pyrrolidine dithiocarbamate (PDTC) is an NF-κB inhibitor, which may indirectly influence MRCL3's activities by modulating the NF-κB pathway.

Concanamycin A

80890-47-7sc-202111
sc-202111A
sc-202111B
sc-202111C
50 µg
200 µg
1 mg
5 mg
$66.00
$167.00
$673.00
$2601.00
109
(2)

Concanamycin A is an ATPase inhibitor that can impair lysosomal acidification and protein degradation processes that involve MRCL3.