mPRδ Activators
mPRδ Activators encompass a spectrum of chemical compounds that, through various mechanisms, enhance the functional activity of mPRδ by modulating the signaling pathways it is involved in. Compounds like Forskolin and Cholera Toxin exert their effects by increasing intracellular levels of cAMP, a pivotal second messenger in G protein-coupled receptor (GPCR) signaling, which is essential for mPRδ function. Forskolin achieves this by directly stimulating adenylyl cyclase, whereas Cholera Toxin irreversibly activates the Gs alpha subunit, leading to sustained adenylyl cyclase activity. Additionally, Sildenafil Citrate and Zaprinast, by inhibiting phosphodiesterase types 5 and 3 respectively, prolong the signaling cascade initiated by cAMP and cGMP, thereby indirectly amplifying mPRδ activity. L-Arginine also supports mPRδ function by serving as a substrate for nitric oxide synthase, culminating in elevated cGMP levels that enhance GPCR signaling. Moreover, PMA and Pertussis Toxin indirectly promote mPRδ activity by modulating protein kinase C and inhibiting the Gi alpha subunit of G proteins, respectively, both leading to alterations in GPCR-mediated signaling.
Further enhancing mPRδ's activity are compounds that modulate intracellular calcium and cGMP levels. A23187, a calcium ionophore, increases intracellular calcium concentration, which can activate calcium-dependent signaling pathways tied to GPCRs, thereby potentially enhancing mPRδ function. YC-1 stimulates soluble guanylyl cyclase, increasing cGMP production and consequently, the activity of cGMP-dependent protein kinases, which can influence GPCR signaling and mPRδ activity. Nicotine acts on nicotinic acetylcholine receptors and can modulate the signaling environment of GPCRs, indirectly affecting mPRδ activity. Lastly, Rolipram, by selectively inhibiting phosphodiesterase 4, raises cAMP levels, which in turn can potentiate GPCR signaling pathways, thereby facilitating the enhancement of mPRδ-mediated functions. Collectively, these activators operate through distinct yet convergent mechanisms, all serving to potentiate the cellular signaling processes in which mPRδ is a critical player, without directly upregulating its expression or binding to the protein as a ligand.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing the production of cyclic AMP (cAMP), a second messenger involved in the regulation of numerous cellular processes. Increased cAMP levels can enhance mPRδ function by promoting G protein-coupled receptor pathway signaling, where mPRδ is a key player. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased levels of cAMP and cGMP by preventing their degradation. This elevation in cyclic nucleotides can enhance the G protein-coupled signaling pathways that mPRδ is associated with, resulting in its increased functional activity. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine serves as a substrate for nitric oxide synthase, leading to the production of nitric oxide (NO), which can activate guanylyl cyclase and increase cGMP levels. Through this mechanism, L-Arginine indirectly enhances mPRδ activity by influencing the cGMP-dependent signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can activate downstream signaling pathways involving G protein-coupled receptors, thereby potentially enhancing the functional activity of mPRδ. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in a myriad of cellular functions. PKC activation can lead to phosphorylation events that modulate G protein-coupled receptor function, thereby potentially enhancing the activity of mPRδ. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis toxin inhibits the Gi alpha subunit, preventing inhibition of adenylyl cyclase. This disinhibition can lead to increased cAMP levels, thereby potentially enhancing the signaling pathways that mPRδ is involved in. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is a selective inhibitor of phosphodiesterase types 3 and 5, leading to an increase in cGMP levels. By sustaining cGMP signaling, it can indirectly enhance mPRδ signaling pathways that are influenced by cGMP-dependent protein kinases. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $32.00 $122.00 $214.00 $928.00 | 9 | |
YC-1 is a soluble guanylyl cyclase activator, resulting in increased cGMP production. The enhancement of cGMP signaling can lead to activation of cGMP-dependent protein kinases and subsequent enhancement of mPRδ activity by influencing pathways that converge on G protein-coupled receptor signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor, leading to increased cAMP levels within cells. The increase in cAMP enhances signaling through pathways that are modulated by G protein-coupled receptors, such as the one mPRδ is part of, thereby potentially enhancing mPRδ activity. | ||||||