Mot1 Inhibitors
Mot1 inhibitors are chemicals that either directly affect the functional activity of Mot1 or influence signaling events leading to its inhibition. Wortmannin and LY294002 are PI3K inhibitors that can indirectly affect Mot1's ATPase activity by decreasing ATP production in the cell. This is due to PI3K's role in the signaling pathway that promotes cellular ATP production. Trifluoperazine and Verapamil, on the other hand, affect calcium signaling in the cell. Trifluoperazine does this by inhibiting calmodulin, while Verapamil does it by blocking calcium channels. These changes in calcium signaling can indirectly affect the ATPase activity of Mot1, as calcium ions are known to influence this activity.
2-deoxy-D-glucose, Thapsigargin, Nigericin, Oligomycin A, Monensin, Valinomycin, Azide, and FCCP are other inhibitors that can affect the ATPase activity of Mot1 by influencing ATP production in the cell. 2-deoxy-D-glucose inhibits glycolysis, Thapsigargin inhibits the SERCA pump, Nigericin and Valinomycin are ionophores that disrupt ion gradients across the mitochondrial membrane, Oligomycin A inhibits ATP synthase, Azide inhibits cytochrome C oxidase, and FCCP uncouples oxidative phosphorylation.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor which can indirectly affect the ATPase activity of Mot1. By inhibiting the PI3K/AKT pathway, Wortmannin can cause a decrease in cellular ATP levels which can inhibit Mot1's ATPase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is similar to Wortmannin as it is also a PI3K inhibitor. It indirectly affects Mot1 by causing a decrease in ATP production, which is required for Mot1's ATPase activity. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $57.00 $101.00 | 9 | |
Trifluoperazine is a calmodulin inhibitor. By inhibiting calmodulin, Trifluoperazine can affect calcium signaling in the cell. Since calcium ions can influence ATPase activity, this could indirectly affect the ATPase activity of Mot1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker. By blocking calcium channels, Verapamil decreases intracellular calcium levels which can indirectly affect the ATPase activity of Mot1. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-deoxy-D-glucose inhibits glycolysis, thus decreasing ATP production in the cell. This can indirectly affect the ATPase activity of Mot1 as it needs ATP to function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that increases intracellular calcium levels. This can indirectly affect the ATPase activity of Mot1. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Nigericin is a potassium ionophore that can disrupt ATP production by disrupting the proton gradient across the mitochondrial membrane. This can indirectly affect the ATPase activity of Mot1. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin A is an inhibitor of ATP synthase that decreases ATP production in the cell. This can indirectly affect the ATPase activity of Mot1. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that can disrupt ATP production by disrupting the sodium gradient across the mitochondrial membrane. This can indirectly affect the ATPase activity of Mot1. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin is a potassium ionophore that can disrupt ATP production by disrupting the potassium gradient across the mitochondrial membrane. This can indirectly affect the ATPase activity of Mot1. | ||||||