MOR-1 Inhibitors
MOR-1 inhibitors belong to a distinct chemical class designed to target and modulate the activity of the mu opioid receptor 1, abbreviated as MOR-1. Mu opioid receptors are a subclass of opioid receptors found primarily in the central nervous system and are known for their pivotal role in mediating the effects of endogenous opioid peptides and exogenous opioids, such as morphine. These receptors play a crucial role in modulating pain perception, reward pathways, and mood regulation. MOR-1, in particular, is a subtype of the mu opioid receptor family and is widely expressed in the brain and spinal cord. MOR-1 inhibitors are characterized by their ability to interact with MOR-1, leading to either the inhibition or modulation of receptor activation.
The development of MOR-1 inhibitors has garnered significant interest in the field of pharmacology and neuroscience due to their potential to influence the opioid system's functioning without directly engaging in the opioid receptor activation pathway. These compounds can exert their effects by binding to MOR-1 and either blocking its activation or altering its signaling in a manner that differs from traditional opioid agonists. Researchers continue to investigate MOR-1 inhibitors as a means of unraveling the intricate nuances of opioid receptor signaling and potentially developing new strategies for managing pain and related neurological disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Naloxone | 465-65-6 | sc-477809 | 200 mg | $300.00 | 5 | |
Naloxone is a well-known opioid receptor antagonist that can competitively bind to OPRM1 and block its activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure and influence gene expression, potentially downregulating the expression of specific genes. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methylation inhibitor and may lead to the reactivation of silenced genes, but it could also indirectly affect the expression of other genes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is another histone deacetylase inhibitor that can modify chromatin and influence gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation, which could indirectly influence gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA synthesis, affecting gene expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis at the level of translation, affecting overall protein expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, affecting mRNA synthesis and thereby gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a natural ligand for estrogen receptors, 17-β-Estradiol can modulate gene expression upon receptor binding. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine affects various signaling pathways and has been shown to have broad effects on cellular function, including potential influences on gene expression. | ||||||