Date published: 2026-2-14

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MOR-1 Activators

MOR-1 activators, also known as mu-opioid receptor-1 activators, belong to a class of chemical compounds that interact specifically with the MOR-1 subtype of the mu-opioid receptor (MOR). These receptors are primarily found in the central nervous system and play a crucial role in mediating the body's response to pain and stress. MOR-1 activators are a diverse group of molecules, encompassing both natural and synthetic compounds, which have the ability to modulate the activity of the MOR-1 receptor. At the molecular level, MOR-1 activators exhibit a high affinity for MOR-1 receptors, leading to their activation or inhibition. Activation of these receptors can trigger a cascade of intracellular signaling events, ultimately resulting in analgesia, euphoria, and other physiological responses associated with the opioid system. The chemical structure of MOR-1 activators can vary widely, with some compounds closely resembling endogenous opioid peptides like endorphins and enkephalins, while others are entirely synthetic in nature.

MOR-1 activators have garnered significant attention in both scientific research due to their profound effects on the central nervous system. Researchers continue to study these compounds to gain a deeper understanding of their mechanism of action and applications. While they hold promise in the management of certain medical conditions, it is essential to approach the exploration of MOR-1 activators with caution. Nevertheless, their study remains a critical aspect of neuroscience and pharmacology, shedding light on the intricate workings of the mu-opioid receptor system.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels, which can lead to the activation of protein kinase A (PKA) and may subsequently influence MOR-1 expression.

Adenosine 3′,5′-cyclic monophosphate

60-92-4sc-217584
sc-217584A
sc-217584B
sc-217584C
sc-217584D
sc-217584E
100 mg
250 mg
5 g
10 g
25 g
50 g
$116.00
$179.00
$265.00
$369.00
$629.00
$1150.00
(1)

cAMP serves as a second messenger in various biological processes. It activates PKA, and through this pathway, it might regulate the transcription factors influencing MOR-1 expression.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC), which can modulate various signaling pathways and transcription factors, potentially resulting in increased MOR-1 expression.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

Dexamethasone is a synthetic glucocorticoid that can bind to the glucocorticoid receptor, influencing the transcription of various genes, possibly including those encoding MOR-1.

Dimethyl Sulfoxide (DMSO)

67-68-5sc-202581
sc-202581A
sc-202581B
100 ml
500 ml
4 L
$31.00
$117.00
$918.00
136
(6)

DMSO can influence cell permeability and has been shown to affect the expression of various proteins, though its exact mechanism in potentially inducing MOR-1 expression remains less clear.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Sodium butyrate is a histone deacetylase inhibitor that can lead to changes in chromatin structure, influencing the accessibility of transcription factors to DNA, potentially affecting MOR-1 expression.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium chloride affects various signaling pathways including the Wnt signaling pathway. It has the potential to modulate gene expression, possibly including MOR-1.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$71.00
$163.00
$296.00
2
(1)

Vitamin D3, upon activation, binds to the vitamin D receptor, influencing the transcription of target genes. It could potentially play a role in regulating MOR-1 expression.