MOF Inhibitors
The MOF Inhibitors constitute a diverse group of chemical compounds designed to modulate the activity of MOF (Males absent on the first), a histone acetyltransferase crucial for histone acetylation and epigenetic regulation. Direct inhibitors, such as Mofezolac, MG-149, C646, TMP195, and EPZ004777, act by specifically targeting the histone acetyltransferase activity of MOF. These compounds disrupt the enzymatic function of MOF, leading to altered chromatin structure and gene expression.
Indirect inhibitors, exemplified by MS-275, Anacardic Acid, Curcumin, Quisinostat, Scriptaid, PCI-24781, and Garcinol, modulate MOF activity by targeting histone deacetylases (HDACs). By enhancing the deacetylation of histones, these compounds counteract the acetylation catalyzed by MOF, influencing the dynamic equilibrium of histone modifications. This modulation of histone acetylation indirectly impacts MOF-mediated epigenetic regulation, providing a different avenue to regulate chromatin structure and gene expression. In summary, MOF Inhibitors employ both direct and indirect mechanisms to influence MOF activity, offering researchers a versatile toolkit to investigate the role of MOF in epigenetic processes. These compounds hold potential for elucidating the intricate mechanisms of histone acetylation and chromatin remodeling, contributing to a deeper understanding of epigenetic regulation in cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275, also known as Entinostat, is a chemical inhibitor that indirectly modulates MOF by targeting histone deacetylases (HDACs). It enhances the deacetylation of histones, counteracting the acetylation catalyzed by MOF. This indirect inhibition alters the balance of histone acetylation, affecting chromatin structure and gene expression regulated by MOF. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic Acid is a natural compound that indirectly inhibits MOF by affecting histone acetylation. It functions as a histone acetyltransferase (HAT) inhibitor, influencing the enzymes responsible for acetylating histones, including MOF. By disrupting histone acetylation, Anacardic Acid indirectly impacts the epigenetic regulation mediated by MOF, altering chromatin structure and gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound that indirectly influences MOF by affecting histone acetylation. It acts as a histone acetyltransferase (HAT) inhibitor, disrupting the acetylation of histones, including the substrate targeted by MOF. This indirect inhibition alters the epigenetic regulation mediated by MOF, leading to changes in chromatin structure and gene expression. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
Quisinostat (JNJ-26481585) is a chemical inhibitor that indirectly influences MOF by targeting histone deacetylases (HDACs). It enhances the deacetylation of histones, counteracting the acetylation catalyzed by MOF. This indirect inhibition alters the balance of histone acetylation, affecting chromatin structure and gene expression regulated by MOF. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid is a chemical compound that indirectly modulates MOF by targeting histone deacetylases (HDACs). It enhances the deacetylation of histones, counteracting the acetylation catalyzed by MOF. This indirect inhibition alters the balance of histone acetylation, affecting chromatin structure and gene expression regulated by MOF. Scriptaid represents an indirect mechanism to modulate MOF activity by influencing the dynamic equilibrium of histone acetylation and deacetylation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a chemical inhibitor that directly targets MOF by interfering with its histone acetyltransferase activity. It disrupts the acetylation of histones, leading to altered chromatin structure and gene expression. This direct inhibition of MOF by C646 hampers its role in epigenetic regulation, influencing cellular processes dependent on histone acetylation. | ||||||
PCI-24781 | 783355-60-2 | sc-364565 sc-364565A | 5 mg 50 mg | $186.00 $1357.00 | 1 | |
PCI-24781 is a chemical inhibitor that indirectly modulates MOF by targeting histone deacetylases (HDACs). It enhances the deacetylation of histones, counteracting the acetylation catalyzed by MOF. This indirect inhibition alters the balance of histone acetylation, affecting chromatin structure and gene expression regulated by MOF. PCI-24781 represents an indirect mechanism to modulate MOF activity by influencing the dynamic equilibrium of histone acetylation and deacetylation. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a chemical inhibitor that directly targets MOF by specifically inhibiting its histone acetyltransferase activity. This direct inhibition interferes with the acetylation of histones, leading to altered chromatin structure and gene expression. EPZ004777 provides a direct means to modulate MOF activity by disrupting its enzymatic function crucial for the epigenetic regulation of chromatin. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Garcinol is a natural compound that indirectly influences MOF by affecting histone acetylation. It functions as a histone acetyltransferase (HAT) inhibitor, influencing the enzymes responsible for acetylating histones, including MOF. By disrupting histone acetylation, Garcinol indirectly impacts the epigenetic regulation mediated by MOF, altering chromatin structure and gene expression. | ||||||