MLZE Inhibitors
MLZE (Metastasis-associated Lung Adenocarcinoma Transcript 1-Like Zinc Finger Protein) inhibitors are a class of chemical compounds that specifically target the MLZE protein, which is involved in various cellular processes. MLZE is a zinc finger protein, a family known for its role in binding to DNA and regulating gene expression. The inhibition of MLZE is of interest primarily because of its involvement in cellular mechanisms related to gene transcription, protein-protein interactions, and potentially cell signaling pathways. Zinc finger proteins, such as MLZE, typically act as transcription factors, meaning that they influence the expression of other genes, making them pivotal in the regulation of many biological pathways, including cell growth and differentiation.
Chemically, MLZE inhibitors are structured to interfere with the interaction of MLZE with DNA or other proteins. Many compounds in this class exhibit high specificity for the MLZE protein due to their unique chemical scaffolds, which allow them to fit precisely into the protein's binding site. These inhibitors typically form hydrogen bonds, van der Waals interactions, and sometimes coordinate directly with the zinc ion within the zinc finger domain. The inhibition can prevent the normal function of MLZE, leading to downstream effects on cellular processes like transcriptional regulation. Research into MLZE inhibitors focuses on understanding their impact on molecular biology and elucidating the mechanistic pathways by which MLZE contributes to cellular function. This is critical for advancing our knowledge of zinc finger proteins and their roles in broader biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D may inhibit Gasdermin C expression by interfering with RNA polymerase activity, potentially disrupting the transcription of Gasdermin C mRNA. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is suggested to inhibit Gasdermin C expression by inducing DNA damage and triggering cellular stress responses that may downregulate Gasdermin C transcription. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide may inhibit Gasdermin C expression by inducing DNA damage and activating stress response pathways, potentially leading to decreased Gasdermin C transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin could potentially inhibit Gasdermin C expression by interfering with the binding of transcription factors to the Gasdermin C gene promoter, reducing its transcription. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is suggested to inhibit Gasdermin C expression by inducing DNA damage and triggering cellular stress responses that may downregulate Gasdermin C transcription. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin may inhibit Gasdermin C expression by inducing DNA damage and activating stress response pathways, potentially leading to decreased Gasdermin C transcription. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine could potentially inhibit Gasdermin C expression by inducing DNA damage and interfering with the function of key transcriptional regulators of Gasdermin C. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is suggested to inhibit Gasdermin C expression by inducing DNA damage and triggering cellular stress responses that may downregulate Gasdermin C transcription. | ||||||
Streptonigrin | 3930-19-6 | sc-500892 sc-500892A | 1 mg 5 mg | $102.00 $357.00 | 1 | |
Streptonigrin may inhibit Gasdermin C expression by inducing DNA damage and activating stress response pathways, potentially leading to decreased Gasdermin C transcription. | ||||||
Thiostrepton | 1393-48-2 | sc-203412 sc-203412A | 1 g 5 g | $115.00 $415.00 | 10 | |
Thiostrepton could potentially inhibit Gasdermin C expression by interfering with the binding of transcription factors to the Gasdermin C gene promoter, reducing its transcription. | ||||||