Date published: 2026-7-21

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MLKL Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of MLKL monoclonal antibodies for research focused on understanding cell death and inflammation mechanisms. MLKL monoclonal antibodies are suitable for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Mixed lineage kinase domain-like protein (MLKL) plays a crucial role in necroptosis, a form of programmed cell death that is distinct from apoptosis. By mediating the cellular response to stress and inflammation, MLKL is essential for maintaining tissue homeostasis and regulating immune responses. Understanding MLKL function is vital for elucidating its involvement in various diseases, including neurodegenerative disorders and cancer. Researchers studying MLKL can explore its role in cell signaling pathways and inflammatory responses. MLKL research continues to reveal new insights into disease mechanisms and potential therapeutic targets. Current investigations focus on how MLKL influences cell death decisions and inflammatory signaling cascades. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific understanding of MLKL's role in health and disease.

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MLKL Antibodies

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MLKL Antibody (3B2)

sc-293201mouse IgG2a κ371-471 (h)WB, IP, IF, IHC(P), FCM, ELISAh
15
(5)

MLKL siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

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MLKL siRNA (h)

sc-93430hGene SilencingN/A
5
(0)

MLKL shRNA Plasmid (h)

sc-93430-SHhGene SilencingPuromycin
5
(0)

MLKL shRNA (h) Lentiviral Particles

sc-93430-VhGene SilencingPuromycin
5
(0)

MLKL siRNA (m)

sc-149468mGene SilencingN/A
2
(0)

MLKL shRNA Plasmid (m)

sc-149468-SHmGene SilencingPuromycin
2
(0)

MLKL shRNA (m) Lentiviral Particles

sc-149468-VmGene SilencingPuromycin
2
(0)

MLKL CRISPR Knockout (KO) and HDR Plasmids

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MLKL CRISPR/Cas9 KO Plasmid (h2)

sc-401248-KO-2Gene Knockouth0
(0)

MLKL HDR Plasmid (h2)

sc-401248-HDR-2Homology Directed Repairh0
(0)

MLKL CRISPR/Cas9 KO Plasmid (m)

sc-428931Gene Knockoutm0
(0)

MLKL HDR Plasmid (m)

sc-428931-HDRHomology Directed Repairm0
(0)

MLKL CRISPR Double Nickase Plasmids

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MLKL Double Nickase Plasmid (h)

sc-401248-NICGene Knockouth0
(0)

MLKL Double Nickase Plasmid (h2)

sc-401248-NIC-2Gene Knockouth0
(0)

MLKL Double Nickase Plasmid (m)

sc-428931-NICGene Knockoutm0
(0)

MLKL Double Nickase Plasmid (m2)

sc-428931-NIC-2Gene Knockoutm0
(0)

MLKL CRISPR Activation Plasmids and Lentiviral Particles

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MLKL CRISPR Activation Plasmid (h)

sc-401248-ACTGene Activationh0
(0)

MLKL CRISPR Activation Plasmid (h2)

sc-401248-ACT-2Gene Activationh0
(0)