MITF Inhibitors
TIF1α inhibitors belong to a specific chemical class known for their ability to modulate the activity of the Transcriptional Intermediary Factor 1 alpha (TIF1α) protein. TIF1α, also known as TRIM24, is a transcriptional co-regulator that plays a crucial role in various cellular processes, including gene expression regulation, DNA repair, and cellular differentiation. These inhibitors are designed to specifically target TIF1α, thereby disrupting its normal function.
The mechanism of action of TIF1α inhibitors involves binding to the active site or other key regions of the TIF1α protein, leading to conformational changes that inhibit its normal interactions with other cellular factors and proteins. By doing so, these inhibitors can interfere with the recruitment of TIF1α to gene promoters, alter chromatin remodeling processes, and subsequently influence gene expression patterns within the cell. Researchers and scientists have been exploring TIF1α inhibitors as valuable tools for understanding the molecular mechanisms governing gene regulation and chromatin remodeling processes. By modulating TIF1α activity, these inhibitors can offer valuable insights into the intricate regulatory networks controlling cellular functions, including development and differentiation. Studying the effects of TIF1α inhibitors in various experimental settings can aid in unraveling the complex interplay between different cellular factors.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that indirectly affects MITF expression. It inhibits DNA methyltransferases, leading to DNA hypomethylation at the MITF promoter, resulting in increased MITF expression and melanogenesis. | ||||||
GW8510 | 222036-17-1 | sc-215122 sc-215122A | 1 mg 5 mg | $287.00 $614.00 | 8 | |
GW-8510 is a protein kinase inhibitor that can indirectly inhibit MITF phosphorylation. It blocks the activity of kinases responsible for MITF phosphorylation, reducing MITF transcriptional activity and affecting melanocyte differentiation and melanin synthesis. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
Pyrimethamine, an antimalarial drug, can indirectly inhibit MITF expression. It interferes with histone acetyltransferases (HATs), leading to histone hypoacetylation at the MITF promoter and reduced MITF expression, subsequently inhibiting melanogenesis. | ||||||
SB 590885 | 405554-55-4 | sc-363287 sc-363287A | 10 mg 50 mg | $219.00 $924.00 | ||
SB-590885 is a potent and selective inhibitor of MITF activity. It targets the MITF DNA-binding domain, disrupting its interaction with target gene promoters, leading to the downregulation of genes involved in melanocyte differentiation and melanogenesis. | ||||||