MITF Activators
Common MITF Activators include, but are not limited to Forskolin CAS 66575-29-9, α-Melanocyte stimulating hormone CAS 581-05-5, Retinoic Acid, all trans CAS 302-79-4, Vemurafenib CAS 918504-65-1 and Trichostatin A CAS 58880-19-6.
MITF Activators constitute a specific category of chemical compounds known for their capacity to modulate the activity of microphthalmia-associated transcription factor (MITF). This chemical class functions by interacting with and enhancing the signaling pathways associated with MITF, a transcription factor that plays a critical role in regulating various cellular processes, including melanocyte development, pigmentation, and differentiation. MITF is acknowledged for its involvement in orchestrating gene expression patterns that influence melanin synthesis and melanocyte function.
MITF Activators exert their influence through specific molecular interactions that may amplify the downstream effects of MITF-mediated signaling, contributing to the fine-tuning of melanocyte-specific gene expression, pigmentation, and cellular responses to environmental cues. The intricate mechanisms through which MITF Activators impact MITF-related pathways remain an area of ongoing scientific exploration, offering insights into the complex interplay between transcriptional regulation, cellular identity, and melanin production. The specific ways in which this chemical class engages with MITF underscore its significance in unraveling the intricacies of melanocyte biology and enhancing our understanding across various scientific domains.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a natural compound found in the Indian coleus plant, increases intracellular cAMP levels and activates MITF expression by stimulating CREB binding to the MITF promoter. | ||||||
α-Melanocyte stimulating hormone | 581-05-5 | sc-364762 sc-364762A sc-364762B | 1 mg 5 mg 25 mg | $110.00 $250.00 $945.00 | ||
α-MSH, a melanocortin peptide, activates the melanocortin-1 receptor (MC1R) pathway, leading to MITF activation and melanogenesis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid (ATRA) and other retinoids activate MITF expression during cellular differentiation and melanocyte development. | ||||||
Vemurafenib | 918504-65-1 | sc-364643 sc-364643A | 10 mg 50 mg | $117.00 $423.00 | 11 | |
Vemurafenib, a targeted therapy for melanoma, modulates the BRAF/MEK/ERK pathway and can influence MITF expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase (HDAC) inhibitor, impacts MITF expression through chromatin remodeling. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-estradiol, an estrogen receptor agonist, can activate MITF expression, affecting melanocyte development. | ||||||