MIBP Inhibitors
MIBP inhibitors, short for Mitotic Interfering with Microtubule Binding Protein inhibitors, are a class of chemical compounds that play a crucial role in cell biology and cellular processes. These inhibitors are primarily characterized by their ability to disrupt the normal functioning of microtubules, which are dynamic cytoskeletal structures made up of tubulin protein subunits. Microtubules are essential for several cellular processes, including cell division, intracellular transport, and maintenance of cell shape. MIBP inhibitors are designed to interfere with the binding of microtubule-associated proteins (MAPs) to microtubules, consequently impeding their polymerization and depolymerization dynamics. This disruption leads to various cellular effects, making MIBP inhibitors valuable tools for understanding fundamental cell biology and their potential applications in various research contexts.
MIBP inhibitors can be classified into several subclasses based on their specific mechanism of action and chemical structure. Some of these compounds act by stabilizing microtubules, preventing their disassembly, while others destabilize them, promoting depolymerization. The modulation of microtubule dynamics by MIBP inhibitors has far-reaching implications for studying cell division processes, such as mitosis and meiosis, as well as exploring intracellular transport mechanisms.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FK-866 | 658084-64-1 | sc-205325 sc-205325A | 5 mg 10 mg | $143.00 $250.00 | 12 | |
A potent inhibitor of NAMPT, which could lead to decreased NAD+ levels, indirectly affecting NRK2 substrate availability. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
As a product inhibitor, it can potentially decrease the activity of NRK2 by feedback inhibition. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to impact lysosomal pH and could alter NRK2 localization or stability indirectly. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that may influence NAD+ biosynthesis pathways and could modulate NRK2 activity indirectly. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
An inhibitor of sirtuin enzymes that could alter NAD+ levels, indirectly affecting NRK2 functions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that may affect NAD+ metabolism and thereby NRK2 activity. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $306.00 $963.00 $7980.00 | 1 | |
Can modulate the malate-aspartate shuttle, potentially influencing NAD+ levels and NRK2 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, which can regulate NAD+ levels and potentially NRK2 activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Inhibits PARP enzymes, potentially increasing NAD+ availability and indirectly affecting NRK2. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
As a precursor to FMN and FAD, it might play a role in cellular redox status, indirectly affecting NRK2. | ||||||