MGST3 Inhibitors
MGST3 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of microsomal glutathione S-transferase 3 (MGST3), an enzyme that belongs to the superfamily of glutathione S-transferases (GSTs). MGST3 is a membrane-bound enzyme primarily involved in the detoxification of reactive electrophilic compounds through conjugation with glutathione, a tripeptide composed of glutamine, cysteine, and glycine. The enzyme plays a significant role in cellular defense mechanisms against oxidative stress and toxic intermediates generated during metabolism. MGST3 catalyzes the conjugation reaction between glutathione and a variety of electrophilic substrates, facilitating their elimination from the cell. Inhibitors of MGST3 are studied to understand the role of this enzyme in biochemical processes, particularly regarding its interaction with oxidative stress pathways and lipid peroxidation.
Chemically, MGST3 inhibitors are diverse in structure, but they typically feature functional groups that can bind to or block the enzyme's active site, preventing the conjugation of glutathione with its substrates. These inhibitors are often explored in biochemical studies to elucidate the mechanistic aspects of MGST3 activity. For instance, inhibition studies using these compounds can help to dissect the enzyme's catalytic mechanism and its role in modulating intracellular redox states. Researchers may employ structural analysis techniques such as X-ray crystallography or molecular docking to better understand how these inhibitors interact with MGST3 on a molecular level. By disrupting the function of MGST3, these inhibitors can help shed light on broader metabolic processes, including the regulation of oxidative stress and the detoxification of xenobiotic compounds.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate MGST3 expression by inhibiting the activation of NF-κB, a transcription factor that can upregulate the expression of genes involved in inflammatory responses, including potentially those of detoxification enzymes like MGST3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could decrease MGST3 levels by promoting the activation of sirtuins that lead to the deacetylation of histones at the MGST3 gene locus, thus silencing its transcriptional activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may reduce the expression of MGST3 through the induction of the antioxidant response element (ARE) pathway, which can alter the expression of various genes involved in the detoxification process. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram might inhibit the expression of MGST3 by disrupting the normal degradation of transcription factors that are instrumental in the expression of this enzyme, thereby leading to decreased MGST3 levels. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate has the potential to decrease MGST3 expression by attenuating the activity of NF-κB and other inflammatory signaling molecules, leading to reduced transcription of inflammation-related genes. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine could inhibit the expression of MGST3 by interfering with cellular signaling pathways responsible for the activation of genes related to the body's stress response, which may include MGST3. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol might lead to the downregulation of MGST3 expression by altering estrogen receptor signaling pathways, which could extend to the transcriptional control of genes like MGST3. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $36.00 $64.00 $87.00 $413.00 $668.00 $65.00 | 8 | |
3,3'-Diindolylmethane may decrease the transcription of MGST3 through its influence on estrogen metabolism, which can extend to a broad range of genes including those involved in detoxification. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may inhibit MGST3 transcription by binding to retinoic acid receptors that interact with promoter regions of specific genes, potentially repressing the transcriptional activity of the MGST3 gene. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could reduce the expression of MGST3 by hindering the folate pathway, which is crucial for the synthesis of purines and pyrimidines, thus affecting the proliferation of cells and their capacity to express certain genes. | ||||||