METRNL Activators
METRNL Activators are a selected range of chemical compounds that are theorized to increase the functional activity of METRNL through their actions on various metabolic and inflammatory pathways. Compounds such as Rosiglitazone, Pioglitazone, and Fenofibrate exert their effects through activation of PPAR-gamma and PPAR-alpha, respectively, leading to enhanced insulin sensitivity and lipid metabolism, which are processes where METRNL is potentially involved. Palmitoylethanolamide and Oleoylethanolamide, both PPAR-alpha agonists, have the potential to modulate lipid metabolism, thus influencing METRNL's role in these pathways.
Additionally, compounds like Curcumin and Berberine that have anti-inflammatory properties could support METRNL's activity by reducing inflammation and modulating metabolic pathways associated with METRNL's function. Alpha-lipoic acid, with its impact on mitochondrial function, may also facilitate the metabolic effects of METRNL. Capsaicin's activation of TRPV1 channels andsubsequent release of neuropeptides like CGRP may influence the immune and metabolic functions where METRNL is implicated. The omega-3 fatty acids, EPA and DHA, known for their roles in lipid metabolism and anti-inflammatory responses, can also be considered indirect activators of METRNL, potentially enhancing its participation in these physiological processes. The collection of these chemical activators, through their distinct yet interrelated effects on cellular signaling and metabolism, provides a multi-faceted approach to augmenting the functional activity of METRNL without directly increasing its expression or acting on the protein in a direct manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP enhances the PKA signaling pathway, which can phosphorylate proteins involved in inflammatory responses where METRNL is known to play a role. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK which is involved in energy homeostasis. Activation of AMPK can lead to downstream effects on metabolic processes, potentially enhancing the role of METRNL in energy expenditure and glucose metabolism. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPAR-gamma agonist which is implicated in adipocyte differentiation. Activation of PPAR-gamma might enhance the role of METRNL in adipose tissue function and systemic metabolism. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, another PPAR-gamma agonist, could indirectly enhance METRNL's activity by modulating lipid metabolism and increasing insulin sensitivity, processes in which METRNL could be involved. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, enhancing glucose uptake and lipid metabolism. This could indirectly support the role of METRNL in metabolic regulation and anti-inflammatory effects in muscle and adipose tissues. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine serves as a substrate for nitric oxide synthase, leading to the production of nitric oxide (NO), which is involved in vasodilation and blood flow regulation, potentially enhancing METRNL's function in vascular homeostasis. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates AMPK and modulates lipid metabolism, which could support the metabolic effects of METRNL, especially in the context of energy expenditure and glucose homeostasis. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1 receptors, which are involved in pain sensation and inflammation. This activation could potentially enhance the anti-inflammatory role of METRNL in muscle and adipose tissue. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) modulates several signaling pathways including AMPK, which could indirectly augment the activity of METRNL in energy metabolism and anti-inflammatory responses. | ||||||