Mec3 Inhibitors
Mec3 inhibitors are a class of chemicals that can potentially inhibit the function of the Mec3 protein. Mec3, also known as mediator of the DNA damage checkpoint protein 3, is involved in the regulation of DNA damage checkpoint signaling and plays a crucial role in maintaining genome stability. The inhibitors of Mec3 can act through various mechanisms to disrupt its function. Caffeine can interfere with DNA damage checkpoint signaling pathways, disrupting the function of Mec3 in detecting and responding to DNA damage. Wortmannin targets the phosphoinositide 3-kinase (PI3K) pathway, blocking downstream effectors involved in the DNA damage response and inhibiting Mec3-mediated signaling. Cisplatin and hydroxyurea induce DNA damage, disrupting the normal function of Mec3 in detecting and repairing DNA damage. Bleomycin and Etoposide (VP-16) are chemotherapy compounds that also induce DNA damage, inhibiting the activity of Mec3. Camptothecin targets topoisomerase I, leading to DNA damage and inhibition of Mec3. Bleomycin A5, a derivative of bleomycin, induces DNA damage and inhibits Mec3. Aphidicolin interferes with DNA replication and repair processes, disrupting the function of Mec3 in detecting and responding to DNA damage.
Furthermore, VE 821, NU7026, and Olaparib target specific pathways involved in the DNA damage response. VE 821 blocks downstream effectors of the ataxia telangiectasia and Rad3-related (ATR) kinase pathway, inhibiting Mec3-mediated signaling. NU7026 is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks the activation of downstream effectors involved in the DNA damage response, thereby inhibiting Mec3. Olaparib, a PARP inhibitor, disrupts the normal function of Mec3 in detecting and repairing DNA damage. In summary, Mec3 inhibitors are a diverse group of chemicals that can target various pathways involved in the DNA damage response. These inhibitors can disrupt the function of Mec3 in detecting and repairing DNA damage, leading to the inhibition of its activity. By interfering with the normal functioning of Mec3, these chemicals have the potential to impact DNA damage checkpoint signaling and compromise genome stability.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is a natural stimulant that can potentially inhibit Mec3 by interfering with DNA damage checkpoint signaling pathways. It can disrupt the function of Mec3 in detecting and responding to DNA damage, leading to the inhibition of its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a fungal metabolite that can potentially inhibit Mec3 by targeting the phosphoinositide 3-kinase (PI3K) pathway. It can block the activation of downstream effectors involved in the DNA damage response, thereby inhibiting Mec3-mediated signaling. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a chemotherapy compound that can potentially inhibit Mec3 by inducing DNA damage. It can disrupt the normal function of Mec3 in detecting and repairing DNA damage, leading to the inhibition of its activity. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea is an antineoplastic agent that can potentially inhibit Mec3 by interfering with DNA replication and repair processes. It can disrupt the normal function of Mec3 in detecting and responding to DNA damage, leading to the inhibition of its activity. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin is an antibiotic and anticancer compound that can potentially inhibit Mec3 by inducing DNA damage. It can disrupt the normal function of Mec3 in detecting and repairing DNA damage, leading to the inhibition of its activity. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE 821 is a small molecule inhibitor that can potentially inhibit Mec3 by targeting the ataxia telangiectasia and Rad3-related (ATR) kinase pathway. It can block the activation of downstream effectors involved in the DNA damage response, thereby inhibiting Mec3-mediated signaling. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide (VP-16) is a chemotherapy compound that can potentially inhibit Mec3 by inducing DNA damage. It can disrupt the normal function of Mec3 in detecting and repairing DNA damage, leading to the inhibition of its activity. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a natural compound that can potentially inhibit Mec3 by targeting topoisomerase I and inducing DNA damage. It can disrupt the normal function of Mec3 in detecting and repairing DNA damage, leading to the inhibition of its activity. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is an antibiotic that can potentially inhibit Mec3 by interfering with DNA replication and repair processes. It can disrupt the normal function of Mec3 in detecting and responding to DNA damage, leading to the inhibition of its activity. | ||||||