MCM8 Activators
MCM8 (Minichromosome Maintenance Complex Component 8) is a protein involved in DNA replication and repair, playing a critical role in maintaining genomic stability. It belongs to the MCM family of proteins, which are crucial for the initiation and elongation phases of DNA replication during the cell cycle.MCM8 forms a complex with another member of the MCM family, MCM7. This complex, MCM8-MCM7, is essential for the unwinding of DNA at replication forks, a process that allows for the copying of genetic material. The complex also plays a role in homologous recombination, a mechanism that repairs broken DNA strands, thus inhibiting genomic instability and cell death.
MCM8 is particularly important for the repair of replication-associated DNA damage in germ cells. Mutations in the MCM8 gene can lead to conditions such as primary ovarian insufficiency and infertility in women, as well as a predisposition to certain types of cancers.Research has shown that overexpression of MCM8 is linked to poor prognosis in several types of cancers, including breast and ovarian cancers, making it a potential biomarker for these diseases. MCM8 is also implicated in cell proliferation, suggesting its role in cancer progression.The study of MCM8 not only aids in understanding the intricacies of DNA replication and repair, but also provides insights into disease mechanisms and potential targets.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, can influence DNA repair pathways, indirectly affecting MCM8 activity. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea, an inhibitor of ribonucleotide reductase, affects DNA synthesis, potentially impacting MCM8 activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a platinum-based chemotherapy drug, creates DNA cross-links that can influence DNA repair processes involving MCM8. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole, a microtubule polymerization inhibitor, can create stress conditions that indirectly impact DNA replication processes involving MCM8. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU, a pyrimidine analog, interferes with DNA synthesis and repair, potentially affecting the activity of MCM8. | ||||||