MCCD1 Activators
Chemical activators of MCCD1 initiate their effects through various signaling pathways that converge on the modulation of the protein's activity. Forskolin and Isoproterenol both raise intracellular cyclic AMP (cAMP) levels by stimulating adenylyl cyclase, which in turn activates protein kinase A (PKA). PKA is known to phosphorylate a myriad of proteins, and in the context of MCCD1, this can lead to its direct phosphorylation and activation. Similarly, 8-Bromo-cAMP, a more stable cAMP analog, can permeate cells and elicit the same activating effect on PKA, which would then act on MCCD1. Phorbol 12-myristate 13-acetate (PMA) and Oxytocin, through different mechanisms, engage protein kinase C (PKC), which is another kinase that phosphorylates proteins. PKC, upon activation, could target MCCD1 for phosphorylation, thereby altering its activity.
Further activating influences come from Ionomycin and Oxytocin, which increase intracellular calcium levels, potentially activating calmodulin-dependent kinase (CaMK) that may target MCCD1. Ionomycin, as a calcium ionophore, facilitates the influx of calcium ions, while Oxytocin triggers G-protein coupled receptors to increase IP3 and diacylglycerol, leading to calcium release from intracellular stores. Insulin activates the PI3K/AKT signaling pathway, with AKT possibly phosphorylating MCCD1 directly or altering its activity through downstream signaling effects. Epidermal Growth Factor (EGF) engages the MAPK/ERK pathway, with ERK potentially modifying MCCD1 activity through phosphorylation. Hydrogen Peroxide acts as an oxidative signal that can modify the activity of various kinases, which might then influence MCCD1 activity. Anisomycin, through the activation of JNK, could also lead to the phosphorylation and subsequent activity modulation of MCCD1. Finally, Retinoic Acid and Calcitriol, through their gene expression modulatory roles, can alter the activity of kinases and phosphatases that regulate MCCD1, leading to its activation by either direct phosphorylation or through other regulatory mechanisms induced by these compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing the production of cyclic AMP (cAMP), which is a second messenger known to enhance the activity of various proteins through the activation of protein kinase A (PKA). MCCD1, as a protein with functions potentially regulated by PKA, would have increased activity due to phosphorylation by PKA. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in multiple signaling pathways. PKC activation can lead to phosphorylation and subsequent activation of MCCD1 if MCCD1 is a substrate or is regulated by downstream effects of PKC signaling. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation of downstream targets, potentially including MCCD1, resulting in its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby activating calmodulin-dependent kinase (CaMK). If MCCD1 activity is regulated by CaMK, the elevated intracellular calcium levels and CaMK activation would activate MCCD1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/AKT signaling pathway, which can result in the phosphorylation and activation of various downstream proteins. If MCCD1 is a part of or regulated by this pathway, its activation could occur as a consequence of AKT-mediated signaling. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide serves as a signaling molecule that can activate various kinases through oxidative mechanisms. If MCCD1 activity is sensitive to redox changes, the oxidation-related modulation of kinases could result in the activation of MCCD1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylyl cyclase, thereby increasing cAMP levels and activating PKA. PKA can then phosphorylate and activate MCCD1 if MCCD1 is among its substrates. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates the activity of kinases and phosphatases through its influence on gene expression. When these kinases and phosphatases interact with MCCD1, they could activate MCCD1 through direct phosphorylation or dephosphorylation. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $59.00 $176.00 $330.00 $650.00 $950.00 $1800.00 | 4 | |
Oxytocin activates G-protein coupled receptors that can lead to the activation of PLC, which in turn increases IP3 and diacylglycerol, activating PKC. If PKC directly or indirectly activates MCCD1, then oxytocin can lead to the activation of MCCD1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator, and activation of JNK can lead to phosphorylation of various substrates. MCCD1 activation could occur through direct or indirect phosphorylation events mediated by JNK. | ||||||