MC-CPA Inhibitors
Chemical inhibitors of MC-CPA play a crucial role in the direct inhibition of this serine protease by binding to its active site and preventing substrate interaction. Benzamidine, for instance, serves as a competitive inhibitor, occupying the active site of MC-CPA, which results in the prevention of substrate cleavage, a similar mechanism of inhibition is exhibited by Soybean trypsin inhibitor (SBTI) and Aprotinin, both of which form complexes with serine proteases, leading to reversible inhibition. Phenylmethanesulfonyl fluoride (PMSF) and Diisopropylfluorophosphate (DFP) take a more permanent approach by covalently modifying and thus irreversibly inactivating the serine residue at the active site of MC-CPA. This alteration halts the enzymatic activity of MC-CPA by rendering it incapable of hydrolyzing peptide bonds in its substrates.
Further expanding the arsenal of MC-CPA inhibitors, chemicals like 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF), Gabexate mesylate, Nafamostat mesylate, and Camostat mesylate interact with the active site of MC-CPA. AEBSF performs irreversible inhibition by binding to the active serine residue, while Gabexate mesylate, Nafamostat mesylate, and Camostat mesylate inhibit by blocking the access of substrates to the active site of MC-CPA. α1-Antitrypsin functions by a similar mechanism, where it attaches to the active site, preventing substrate cleavage. On the other hand, Leupeptin and Chymostatin inhibit MC-CPA by reversibly binding to the active site, which impedes the protease's catalytic function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $292.00 | 1 | |
Benzamidine is a competitive inhibitor of many serine proteases. MC-CPA is a serine protease, and benzamidine can inhibit its function by binding to its active site, thus preventing the binding and cleavage of its specific substrates. | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $697.00 | 92 | |
PMSF is an irreversible inhibitor of serine proteases. It reacts with the serine residue in the active site of MC-CPA, inactivating the enzyme and thereby inhibiting its proteolytic activity. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
Aprotinin acts as a protease inhibitor by forming reversible stoichiometric complexes with serine proteases. It can inhibit MC-CPA by binding to its active site, which blocks substrate access. | ||||||
Trypsin Inhibitor, soybean | 9035-81-8 | sc-29129 sc-29129A sc-29129B sc-29129C sc-29129D sc-29129F sc-29129E | 50 mg 250 mg 1 g 5 g 10 g 25 g 100 g | $41.00 $135.00 $288.00 $1100.00 $1600.00 $2600.00 $10500.00 | 14 | |
SBTI is known to inhibit serine proteases like trypsin and chymotrypsin and can similarly inhibit MC-CPA by blocking its active site, preventing the cleavage of peptide bonds in substrates. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
AEBSF is a serine protease inhibitor that irreversibly binds to the serine residue in the active site of MC-CPA, inhibiting its enzymatic function. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate mesylate inhibits serine proteases by binding to their active site, which would inhibit MC-CPA activity by preventing substrate access and subsequent cleavage. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $82.00 $306.00 | 4 | |
Nafamostat mesylate is a broad-spectrum serine protease inhibitor that can inhibit MC-CPA by binding to its active site, thus blocking the cleavage of peptide bonds in its substrates. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $43.00 $183.00 $312.00 $624.00 $2081.00 $4474.00 | 5 | |
Camostat mesylate inhibits serine proteases by interacting with their active sites. It can inhibit MC-CPA by preventing the protease from hydrolyzing its peptide substrates. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is an inhibitor of several serine proteases. It can inhibit MC-CPA by reversibly binding to the active site of the protease, thereby blocking substrate access. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $156.00 $260.00 $640.00 $1186.00 $2270.00 | 3 | |
Chymostatin is a specific inhibitor of chymotrypsin-like serine proteases and can inhibit MC-CPA by binding to its active site, which prevents the enzyme from performing its catalytic function on substrates. | ||||||