MBD3L3 Inhibitors
MBD3L3 Inhibitors are a diverse group of chemical compounds that primarily act by altering the methylation status of DNA, which is essential for the binding and function of MBD3L3. MBD3L3, a member of the methyl-CpG binding domain family, recognizes and binds to methylated DNA. This interaction is crucial for its role in chromatin organization and gene expression regulation. Inhibitors like 5-Azacytidine and Zebularine are incorporated into DNA during replication and trap DNA methyltransferases, respectively, leading to a decrease in DNA methylation levels. As a result, the ability of MBD3L3 to bind methylated DNA is compromised, inhibiting its function.
Other inhibitors, such as RG108 and Genistein, directly target DNA methyltransferases, preventing them from adding methyl groups to DNA. This hypomethylation of DNA reduces the binding affinity of MBD3L3 for DNA, thereby inhibiting its functional activity. Compounds like S-adenosyl homocysteine elevate the levels of homocysteine, which competes with S-adenosylmethionine and hampers the methylation process, indirectly decreasing MBD3L3 action. Nitric oxide donors, such as SNAP, and phosphodiesterase inhibitors like caffeine, can modulate intracellular signaling pathways that influence DNA methylation machinery, leading to an environment less conducive to MBD3L3 binding.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Incorporates into DNA, inhibits DNA methyltransferase, leading to decreased DNA methylation and reduced MBD3L3 binding to methylated DNA. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
Directly inhibits DNA methyltransferases, preventing DNA methylation necessary for MBD3L3 to bind, thereby reducing MBD3L3 function. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Increases levels of homocysteine, a competitive inhibitor of S-adenosylmethionine-dependent methyltransferases, decreasing DNA methylation and MBD3L3 activity. | ||||||
Procainamide hydrochloride | 614-39-1 | sc-202297 | 10 g | $52.00 | ||
Inhibits DNA methyltransferases non-selectively, leading to hypomethylation of DNA and decreased MBD3L3 binding to methylated DNA. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Induces hypomethylation of DNA by inhibiting DNA methyltransferases, which reduces the binding sites for MBD3L3 and its functional activity. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
A cytidine analog that traps DNA methyltransferases, thus lowering DNA methylation and diminishing MBD3L3's ability to bind to DNA. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Isoflavone that inhibits DNA methyltransferases, leading to DNA hypomethylation and reduced interaction of MBD3L3 with methylated DNA. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Acts as a phosphodiesterase inhibitor, which can elevate cAMP levels, potentially affecting DNA methylation and decreasing MBD3L3 activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Alters DNA methylation indirectly through its action on aldehyde dehydrogenase, potentially reducing MBD3L3's binding to DNA. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Polyphenol that can inhibit DNA methyltransferases, leading to decreased methylation and consequently lower MBD3L3 binding to DNA. | ||||||