Date published: 2026-2-14

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MARVELD1 Inhibitors

MARVELD1 inhibitors belong to a specific class of chemical compounds that target the MARVELD1 protein, also known as Tricellulin. MARVELD1, an acronym for MARVEL Domain Containing 1,is a crucial component in cellular tight junctions, which are integral to maintaining the integrity and selective permeability of epithelial cell layers. Tight junctions play a fundamental role in regulating paracellular transport, preventing the uncontrolled passage of ions and solutes across the epithelium. The MARVELD1 protein is particularly abundant in tissues with barrier functions, such as the epithelial linings of various organs, including the gastrointestinal and respiratory tracts. The development of MARVELD1 inhibitors has gained attention due to their potential in modulating tight junction function. By selectively inhibiting MARVELD1, these compounds may influence the permeability of epithelial barriers, with potential implications for various physiological processes. Researchers are exploring the structural characteristics of MARVELD1 inhibitors to understand their binding interactions with the protein, aiming to design more potent and specific compounds. This class of inhibitors holds promise for elucidating the intricate regulatory mechanisms of tight junctions.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BYL719

1217486-61-7sc-391001
sc-391001A
sc-391001B
sc-391001C
sc-391001D
sc-391001E
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$391.00
$597.00
$755.00
$1192.00
$5000.00
$9370.00
2
(0)

Alpelisib is a selective PI3K inhibitor that targets the PIK3CA gene, leading to the inhibition of the PI3K/AKT/mTOR pathway. This pathway can regulate MARVELD1 expression, so inhibiting it could decrease MARVELD1 function.

Gefitinib

184475-35-2sc-202166
sc-202166A
sc-202166B
sc-202166C
100 mg
250 mg
1 g
5 g
$63.00
$114.00
$218.00
$349.00
74
(2)

Gefitinib is an EGFR tyrosine kinase inhibitor. By blocking EGFR, it indirectly affects downstream signaling pathways involved in the regulation of MARVELD1, potentially decreasing its activity.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin is an mTOR inhibitor, which interferes with the mTOR signaling pathway. Since MARVELD1 expression can be influenced by this pathway, rapamycin may reduce MARVELD1 activity by inhibiting mTOR.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a potent inhibitor of PI3K, which is upstream of AKT and mTOR. It would decrease MARVELD1 activity by inhibiting the PI3K/AKT/mTOR signaling axis that can regulate MARVELD1.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059 is a MEK inhibitor, which interferes with the MAPK/ERK pathway. The MAPK/ERK pathway can modulate MARVELD1, and inhibition by PD98059 could lead to reduced MARVELD1 activity.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is also a MEK inhibitor affecting the MAPK/ERK pathway. It could indirectly lower MARVELD1 activity by inhibiting this pathway, which is potentially involved in MARVELD1 regulation.

Erlotinib, Free Base

183321-74-6sc-396113
sc-396113A
sc-396113B
sc-396113C
sc-396113D
500 mg
1 g
5 g
10 g
100 g
$87.00
$135.00
$293.00
$505.00
$3827.00
42
(0)

Erlotinib is an EGFR inhibitor like gefitinib and can decrease MARVELD1 activity by inhibiting downstream signaling pathways that may regulate MARVELD1.

Everolimus

159351-69-6sc-218452
sc-218452A
5 mg
50 mg
$131.00
$651.00
7
(1)

Everolimus is a derivative of rapamycin and acts as an mTOR inhibitor. It would inhibit MARVELD1 activity by suppressing the mTOR signaling pathway, which could influence MARVELD1 regulation.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Dasatinib is a broad-spectrum tyrosine kinase inhibitor, which could impact several pathways including those that may regulate MARVELD1, leading to its decreased activity.

Trametinib

871700-17-3sc-364639
sc-364639A
sc-364639B
5 mg
10 mg
1 g
$114.00
$166.00
$947.00
19
(1)

Trametinib is a MEK inhibitor that targets the MAPK/ERK pathway. Inhibition of this pathway could lead to decreased MARVELD1 activity if MARVELD1 is regulated by this pathway.