Date published: 2026-4-12

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MARK2 Inhibitors

MARK2 inhibitors belong to a class of compounds designed to selectively target and modulate the activity of the MARK2 enzyme, also known as microtubule affinity-regulating kinase 2. MARK2 is a serine/threonine protein kinase that plays a crucial role in regulating cellular processes such as cell division, polarity, and intracellular transport. As a member of the AMP-activated protein kinase (AMPK) family, MARK2 is involved in the phosphorylation of microtubule-associated proteins, contributing to the dynamic instability and organization of microtubules within the cytoskeleton. MARK2 inhibitors involve the identification and synthesis of small molecules that can selectively bind to the active site of the enzyme, disrupting its catalytic function. These inhibitors often leverage the structural knowledge of the kinase domain of MARK2 to achieve specificity and potency. The chemical optimization of MARK2 inhibitors involves fine-tuning the molecular structure to enhance their binding affinity and pharmacokinetic properties, with the ultimate goal of providing valuable tools for probing the biological functions of MARK2 and potentially influencing disease-related cellular pathways.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

A known kinase inhibitor that can inhibit MARK2 by binding to the ATP pocket, thereby blocking its kinase activity.

5-Iodotubercidin

24386-93-4sc-3531
sc-3531A
1 mg
5 mg
$153.00
$464.00
20
(2)

An adenosine analog that can inhibit MARK2 by competing with ATP, thus preventing phosphorylation events necessary for MARK2's activity.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

A broad-spectrum kinase inhibitor that may inhibit MARK2 alongside other kinases by altering the phosphorylation state, affecting signaling pathways.

Alsterpaullone

237430-03-4sc-202453
sc-202453A
1 mg
5 mg
$68.00
$312.00
2
(1)

A cyclin-dependent kinase inhibitor that may indirectly affect MARK2's regulatory network by modulating cell cycle-related kinases.

Sotrastaurin

425637-18-9sc-474229
sc-474229A
5 mg
10 mg
$300.00
$540.00
(0)

A protein kinase C inhibitor that may also impact MARK2 function due to cross-talk between PKC and MARK2 signaling pathways.

Bisindolylmaleimide I (GF 109203X)

133052-90-1sc-24003A
sc-24003
1 mg
5 mg
$105.00
$242.00
36
(1)

A class of compounds known for PKC inhibition which may also have off-target effects on MARK2 due to structural similarities in their ATP-binding regions.

Kenpaullone

142273-20-9sc-200643
sc-200643A
sc-200643B
sc-200643C
1 mg
5 mg
10 mg
25 mg
$61.00
$153.00
$231.00
$505.00
1
(1)

Another cyclin-dependent kinase inhibitor that could have an impact on MARK2 through modulation of the cell cycle and associated kinases.

Casein Kinase I Inhibitor, D4476

301836-43-1sc-202522
1 mg
$99.00
6
(1)

Reported as a CK1 inhibitor but due to the conserved nature of the kinase ATP binding site, it may also inhibit MARK2.

PF-4800567 Hydrochloride

1391052-28-0sc-477581
10 mg
$320.00
(0)

A selective inhibitor of MARK2 that competes with ATP binding, thus directly inhibiting its kinase activity.

SCH772984

942183-80-4sc-473205
5 mg
$370.00
5
(0)

An ERK inhibitor that can indirectly affect MARK2 activity through the MAPK signaling pathway, which is interconnected with MARK2s function.