MAGE-A2 Inhibitors
MAGE-A2 inhibitors represent a class of small molecules or compounds specifically designed to target and inhibit the expression or function of the MAGE-A2 gene. MAGE-A2, short for Melanoma Antigen Gene-A2, belongs to a family of cancer-testis antigens that are primarily expressed in various cancerous tissues, particularly in melanomas and other solid tumors. These antigens are of particular interest in cancer research due to their limited expression in normal adult tissues.
The development of MAGE-A2 inhibitors stems from the recognition that the aberrant expression of MAGE-A2 is associated with the growth and progression of certain cancers. These inhibitors work through various mechanisms to disrupt the transcription or translation of the MAGE-A2 gene or interfere with its downstream signaling pathways. By doing so, they aim to inhibit the production or activity of MAGE-A2 protein, which may play a role in promoting tumor cell survival, proliferation, or immune evasion. The design and optimization of MAGE-A2 inhibitors require a deep understanding of the molecular biology and genetics of MAGE-A2, as well as the development of specific molecules capable of selectively targeting this gene without affecting essential cellular functions.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can demethylate DNA, potentially leading to the downregulation of MAGE-A2 expression if methylation is involved in its upregulation in cells. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
As an HDAC inhibitor, Suberoylanilide Hydroxamic Acid can alter chromatin structure and affect gene expression, possibly including genes like MAGE-A2. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-Azacytidine, Decitabine is involved in DNA demethylation, which could downregulate MAGE-A2 expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
It can modulate proteasome activity and may affect protein levels indirectly, potentially influencing MAGE-A2 levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits proteasome activity, which could impact the stability of various proteins, including potentially MAGE-A2. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Another HDAC inhibitor, Romidepsin could alter expression patterns of cancer-testis antigens like MAGE-A2 by changing chromatin accessibility. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
It has HDAC inhibitory activity and may indirectly reduce MAGE-A2 expression by altering histone modifications and gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
As an HDAC inhibitor, MS-275 can affect gene expression profiles, which could include genes like MAGE-A2. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
By inhibiting HDACs, Panobinostat can modulate gene expression and potentially decrease MAGE-A2 levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
It affects various signaling pathways and has been shown to have a broad epigenetic impact that could include suppression of MAGE-A2. | ||||||