MACF1 Activators
The chemical class of MACF1 Activators encompasses a diverse range of compounds that can indirectly influence the activity of MACF1 by modulating cytoskeletal dynamics and associated signaling pathways. These compounds do not directly activate MACF1 but can affect its function by altering the stability, organization, or dynamics of the actin and microtubule cytoskeletons, which are crucial for MACF1's role in cellular processes.
For instance, compounds like Paclitaxel and Nocodazole impact microtubule stability, which is significant as MACF1 functions to crosslink microtubules and actin filaments. Similarly, agents such as Jasplakinolide and Cytochalasin D, which influence actin filament dynamics, can indirectly modulate the activity of MACF1.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates the Wnt/β-catenin pathway. MACF1 has been shown to interact with components of the Wnt signaling pathway, suggesting that activation of this pathway could indirectly modulate MACF1 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels and PKA activation. PKA can phosphorylate various proteins involved in cytoskeletal dynamics, potentially influencing MACF1's role in linking actin and microtubules. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, which could indirectly affect MACF1 function as MACF1 is involved in crosslinking microtubules and actin filaments. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments. By altering the dynamics of the actin cytoskeleton, it can indirectly influence MACF1, which is involved in actin-microtubule interactions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. ROCK influences actin cytoskeletal dynamics; thus, its inhibition can indirectly affect MACF1 function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in actin-myosin contraction. Altering actin dynamics could indirectly influence MACF1 activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, affecting protein phosphorylation status and thereby potentially influencing cytoskeletal dynamics and MACF1 activity. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin inhibits myosin II, impacting actin-myosin interactions and potentially influencing MACF1 function in actin-microtubule crosslinking. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin polymerization. Altering actin dynamics can indirectly affect MACF1, given its role in actin-microtubule crosslinking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. By altering microtubule dynamics, it can indirectly influence MACF1 activity. | ||||||