MA1 Activators
The landscape of MA1 activators unfolds as a diverse ensemble of chemicals that intricately modulate MA1 activity through a plethora of signaling pathways. These compounds, each with its unique mode of action, leave an indelible mark on MA1 either through direct interaction or by skillfully navigating key regulatory pathways. At the forefront, Retinoic Acid emerges as a pivotal player, a ligand for nuclear receptors, activating MA1 with precision through the RXR pathway. Meanwhile, the dynamic duo of Bisindolylmaleimide I and SB216763 takes the stage, indirectly steering MA1 towards activation by inhibiting PKC and GSK-3, effectively dismantling their inhibitory fortifications. Forsaking convention, Forskolin steps into the spotlight, masterfully choreographing MA1 activation through the cAMP pathway, eliciting a cascade of events that culminate in the stimulation of PKA. In a strategic move, LY294002, a PI3K inhibitor, strategically disrupts the negative regulation imposed by PI3K/Akt signaling, setting MA1 free from inhibitory constraints. Calyculin A then emerges as a guardian, sustaining MA1 activation by deftly inhibiting protein phosphatases, ensuring a continuous state of readiness.
Resveratrol introduces an element of epigenetic finesse, activating MA1 through SIRT1 modulation, underscoring the role of intricate regulatory mechanisms. On a different note, H-89 steps in as the dissenter, quelling the influence of PKA, thereby liberating MA1 from its suppressive grasp. A769662, an AMPK activator, joins the orchestration, indirectly activating MA1 by dismantling AMPK-mediated inhibitory barriers. Triciribine disrupts the Akt-mediated negative regulation of MA1, allowing for the emergence of its activated state. BAY 11-7082 assumes a role as a peacemaker, alleviating NF-κB-mediated suppression of MA1. Finally, SU6656, a maestro in its own right, prevents the discordant notes of Src kinase-mediated phosphorylation on MA1, thereby indirectly orchestrating the activation of MA1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates MA1 through the RXR pathway. As a ligand for nuclear receptors, it binds RXR, forming a complex that influences downstream targets, ultimately activating MA1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor, indirectly activating MA1. By inhibiting PKC, it disrupts the downstream signaling cascade, relieving its inhibitory effect on MA1 activation, leading to increased MA1 activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763, a GSK-3 inhibitor, indirectly activates MA1. GSK-3 negatively regulates MA1 through phosphorylation. Inhibition of GSK-3 by SB216763 prevents this phosphorylation, leading to increased MA1 activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates MA1 via the cAMP pathway. It stimulates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP activates protein kinase A (PKA), which in turn activates MA1, highlighting the role of Forskolin in the indirect activation of MA1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly activates MA1. PI3K/Akt negatively regulates MA1, and LY294002 inhibits this pathway, resulting in the relief of MA1 from inhibitory signals and subsequent activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, indirectly activates MA1. By inhibiting protein phosphatases, it maintains phosphorylation on critical residues of proteins in the MA1 signaling pathway, promoting its sustained activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates MA1 through SIRT1 modulation. As a SIRT1 activator, it influences deacetylation of downstream targets, leading to increased MA1 activity. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMPK activator, indirectly activates MA1. AMPK negatively regulates MA1 by phosphorylation. A769662 activates AMPK, leading to downstream effects that relieve the inhibitory influence on MA1, ultimately promoting its activation. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine, an Akt inhibitor, indirectly activates MA1. Akt phosphorylates MA1, negatively regulating its activity. Inhibition of Akt by Triciribine prevents this phosphorylation, leading to the indirect activation of MA1. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an NF-κB inhibitor, indirectly activates MA1. NF-κB negatively regulates MA1 expression. Inhibition of NF-κB by BAY 11-7082 disrupts this inhibitory signaling, leading to increased MA1 activity. | ||||||