LRP2BP (LDL receptor-related protein 2 binding protein) inhibitors are a category of chemical agents specifically designed to modulate the function of the LRP2BP protein. LRP2BP is an intriguing biological entity involved in complex cellular pathways, mainly through its interactions with LRP2 (megalin), a multifunctional receptor implicated in various physiological processes including endocytosis and signal transduction. The intricate nature of these pathways makes the discovery and understanding of inhibitors against LRP2BP a captivating area of scientific research. Inhibitors targeting LRP2BP function could affect the interaction of LRP2BP with LRP2 and other proteins, influencing a cascade of intracellular events and modifying cellular behavior. Developing these inhibitors requires an in-depth exploration of molecular structures and the biochemical interfaces of interaction to design molecules that can efficiently and selectively interrupt the desired pathways.
The design and synthesis of LRP2BP inhibitors necessitate a comprehensive approach that encompasses various fields such as organic chemistry, molecular biology, and computational modeling. Researchers in this area aim to elucidate the precise molecular mechanisms through which these inhibitors exert their modulatory effects, seeking a profound understanding of their specificity, selectivity, and mechanism of action. Advances in this field might contribute to the broader scientific knowledge, enabling the exploration of the biological significance and molecular intricacies of LRP2BP and its associated pathways. Additionally, the study of these inhibitors allows for the exploration of the fundamental aspects of cellular regulation and molecular recognition, facilitating a deeper appreciation of cellular complexity and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 is an AMP-activated protein kinase (AMPK) activator. It phosphorylates LRP2BP to enhance its interaction with AMPK, promoting LRP2BP degradation and reducing its function in lipid metabolism. | ||||||
C75 (racemic) | 191282-48-1 | sc-202511 sc-202511A sc-202511B | 1 mg 5 mg 10 mg | $72.00 $206.00 $290.00 | 9 | |
C75 is an inhibitor of fatty acid synthase (FASN), which indirectly affects LRP2BP by reducing the availability of fatty acids, disrupting lipid metabolism pathways, and subsequently decreasing LRP2BP activity. | ||||||
GW3965 | 405911-09-3 | sc-490151 sc-490151A sc-490151B | 10 mg 50 mg 1 g | $260.00 $872.00 $1637.00 | ||
GW3965 is a synthetic liver X receptor (LXR) agonist. It modulates LRP2BP expression by activating LXR, leading to reduced expression of LRP2BP and decreased cholesterol uptake and lipid metabolism. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin is an activator of AMPK, which indirectly impacts LRP2BP by increasing AMPK phosphorylation and promoting LRP2BP degradation, thus reducing its role in lipid metabolism and cholesterol regulation. | ||||||
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $52.00 | 7 | |
THL is a pancreatic lipase inhibitor that indirectly affects LRP2BP by blocking the digestion and absorption of dietary fats. This reduces the availability of lipids, influencing LRP2BP-related lipid metabolism pathways. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist. It alters LRP2BP expression by activating PPARγ, leading to reduced LRP2BP levels and decreased lipid uptake and metabolism. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Imatinib inhibits multiple kinases, including ABL kinase, which indirectly impacts LRP2BP through kinase signaling pathways. By inhibiting ABL kinase, Imatinib can alter LRP2BP-related cellular functions and lipid metabolism. | ||||||