Date published: 2025-9-10

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LOC100039452 Inhibitors

LOC100039452 inhibitors are a class of chemical compounds developed to target and inhibit the activity of the protein encoded by the gene LOC100039452. This gene is part of a subset of genes identified through genomic research projects, known for their distinct expression patterns and hypothesized roles in cellular biology. The protein encoded by LOC100039452, while not fully characterized, is believed to be involved in specific cellular processes, as suggested by initial genomic and proteomic data. The development of inhibitors for this protein is grounded in a thorough understanding of its molecular structure and the mechanisms by which it functions within cells. The primary objective of designing LOC100039452 inhibitors is to disrupt the protein's functional interactions, thereby gaining insights into its role in cellular processes and potentially modulating these processes. This involves identifying essential domains or active sites on the protein that are crucial for its function and creating molecules that can specifically bind to and inhibit these sites.

The process of developing LOC100039452 inhibitors is intricate and requires collaboration across several scientific disciplines, including biochemistry, molecular biology, and pharmacology. Researchers working on this task concentrate on elucidating the structural details of the LOC100039452 protein. Utilizing a range of advanced techniques, they aim to map out the protein's structure, especially areas that are significant for its function. Understanding these structural aspects is crucial for the precise design of inhibitors that are both specific to their target and effective in their inhibitory action. The interaction between these inhibitors and the LOC100039452 protein is a critical aspect of their effectiveness. The inhibitors must bind to the protein in a manner that disrupts its ability to interact with other cellular components or carry out its normal functions. Typically, this involves the formation of a complex between the inhibitor and specific regions on the protein, necessitating a highly accurate match in molecular structures. In addition to their binding characteristics, the design of LOC100039452 inhibitors also takes into account factors like the compound's stability, solubility, and its ability to reach and interact effectively with the target site within biological systems. Researchers also strive to optimize the pharmacokinetic properties of these inhibitors, ensuring they have suitable hydrophobic and hydrophilic properties and an appropriate molecular size and shape for efficient interaction. The development of LOC100039452 inhibitors showcases the advanced level of current research in molecular targeting and highlights the complexities involved in designing inhibitors for proteins that are relatively uncharacterized but may hold significance in biological processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This compound inhibits DNA methyltransferases, potentially leading to demethylation and reactivation of silenced genes.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

As a histone deacetylase inhibitor, it increases acetylation levels of histones, often associated with active gene transcription.

Mocetinostat

726169-73-9sc-364539
sc-364539B
sc-364539A
5 mg
10 mg
50 mg
$210.00
$242.00
$1434.00
2
(1)

This is also a histone deacetylase inhibitor, which can alter chromatin structure and affect gene expression.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

It intercalates into DNA, inhibiting the progression of RNA polymerase and thus blocking RNA synthesis.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA can activate protein kinase C, which may lead to altered transcription factor activity and gene expression.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

Similar to 5-azacytidine, decitabine is a DNA methyltransferase inhibitor, which can lead to gene demethylation and expression changes.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

This is another histone deacetylase inhibitor that can result in changes in gene expression by affecting chromatin structure.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$260.00
$1029.00
26
(2)

Alpha-amanitin is a potent inhibitor of RNA polymerase II, which is responsible for transcribing mRNA.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

Etoposide inhibits DNA topoisomerase II, leading to DNA damage and potentially affecting gene transcription.

Hydroxyurea

127-07-1sc-29061
sc-29061A
5 g
25 g
$76.00
$255.00
18
(1)

It inhibits ribonucleotide reductase, reducing the pool of deoxyribonucleotides available for DNA synthesis and repair, which can influence gene expression.