LMBR1 Activators
LMBR1 Activators are a diverse array of chemical compounds that indirectly influence the functional activity of LMBR1 through modulation of various cellular signaling pathways. Forskolin, Isoproterenol, and Dibutyryl cyclic-AMP (db-cAMP) all work by increasing intracellular levels of cAMP, which in turn activates PKA. Once activated, PKA can phosphorylate LMBR1 or proteins within its signaling pathway, leading to an enhancement of LMBR1's activity. This mechanism of activation is shared by IBMX, which raises cAMP by inhibiting phosphodiesterases responsible for its breakdown. Additionally, (-)-Epigallocatechin gallate (EGCG) serves to inhibit competitive protein kinases, potentially reducing inhibitory phosphorylation and thereby enhancing LMBR1 pathway signaling. Calyculin A and Okadaic Acid further amplify LMBR1's activity by inhibiting protein phosphatases suchas PP1 and PP2A, which normally act to remove phosphorylation marks from proteins. This inhibition leads to sustained phosphorylation within the LMBR1 signaling cascade, promoting its activity. Similarly, Anisomycin, which activates stress-activated protein kinases like JNK, could initiate a chain of phosphorylation events culminating in the activation of LMBR1.
Calcium signaling is another important modulator of LMBR1 activity, with Ionomycin and A23187 acting as calcium ionophores to increase intracellular calcium levels. The resultant activation of calcium-dependent kinases provides another pathway through which LMBR1 could be phosphorylated and activated. Phorbol 12-myristate 13-acetate (PMA) directly activates PKC, which has numerous substrates that could include LMBR1 or its associated proteins, leading to enhanced LMBR1 activity. Lastly, LY294002, by inhibiting PI3 kinase, alters the phosphorylation landscape of the cell, potentially upregulating signaling pathways that lead to the activation of LMBR1. Collectively, these chemical compounds enact a multifaceted approach to the enhancement of LMBR1 functionality by targeting specific signaling pathways and modifying phosphorylation dynamics to favor LMBR1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts directly on adenylyl cyclase, increasing cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can then phosphorylate specific proteins including LMBR1, leading to its functional activation through post-translational modifications. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Increased Ca2+ can activate calcium-sensitive signaling pathways, which may include kinases that phosphorylate LMBR1, thereby enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a wide range of target proteins. PKC-mediated phosphorylation of LMBR1, or associated proteins in its pathway, could lead to enhanced activity of LMBR1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, indirectly leading to the activation of PKA. PKA can then phosphorylate LMBR1 or associated regulatory proteins, enhancing LMBR1's activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases, potentially reducing competitive phosphorylation on signaling pathways involving LMBR1. This could indirectly enhance LMBR1's activity by minimizing inhibitory signals. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents cAMP degradation, thus indirectly elevating PKA activity. PKA can enhance LMBR1 activity through phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, similar to Ionomycin. This rise in Ca2+ activates calcium-dependent kinases that could phosphorylate and enhance the activity of LMBR1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Db-cAMP is a membrane-permeable cAMP analog that activates PKA. PKA can phosphorylate LMBR1, resulting in enhanced activation of LMBR1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 (PP1) and 2A (PP2A), which prevents dephosphorylation of proteins. This could lead to sustained phosphorylation and activation of LMBR1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases like JNK. Activation of these kinases could lead to phosphorylation and activation of signaling pathways that include LMBR1. | ||||||