LCE3B Inhibitors
LCE3B Inhibitors are a set of chemical compounds that interfere with specific signaling pathways and transcription factors, resulting in the suppression of LCE3B protein activity. Epigallocatechin gallate (EGCG) and Caffeic acid, both possessing antioxidant properties, inhibit NF-κB, a transcription factor that upregulates LCE3B expression in response to inflammatory stimuli. By suppressing NF-κB activation, these compounds diminish the induction of LCE3B, effectively reducing its functional presence. Another compound, Curcumin, targets the PPAR-γ pathway, which is implicated in LCE3B gene regulation. By modulating PPAR-γ activity, Curcumin leads to a decrease in LCE3B expression and its associated functions. Similarly, Resveratrol indirectly suppresses LCE3B through inhibition of the STAT3 signaling pathway, while Sulforaphane influences chromatin structure via histone deacetylase inhibition, both contributing to reduced LCE3B expression. Indirubin and Quercetin target GSK-3β and JNK signaling pathways, respectively, which are involved in cellular stress responses and could regulate LCE3B expression, thus leading to its functional inhibition when these pathways are dampened.
Apigenin and Kaempferol inhibit the PI3K/Akt and ERK1/2 signaling pathways, respectively, pathways potentially involved in the control of LCE3B expression. By diminishing the signals through these pathways, these flavonoids contribute to the decreased activity of LCE3B. Genistein, by modulating estrogen receptor signaling, and Lycopene, by inhibiting IGF-1R signaling, both affect pathways that can upregulate LCE3B, thus leading to its functional inhibition when these pathways are influenced. Finally, Retinoic acid modulates RAR, which can have downstream effects on LCE3B expression, adding another layer of regulation that can suppress the activity of LCE3B, illustrating the diverse mechanisms through which these compounds can achieve the inhibition of the LCE3B protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea with antioxidant properties. It inhibits the activation of NF-κB, a transcription factor that can upregulate LCE3B expression in keratinocytes. By suppressing NF-κB, EGCG diminishes the induction of LCE3B, leading to its functional inhibition. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a bioactive compound in turmeric with anti-inflammatory properties. It interferes with the PPAR-γ signaling pathway which has been implicated in the regulation of the LCE3B gene. By modulating PPAR-γ activity, curcumin can lead to decreased expression of LCE3B and thus its functional inhibition. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a stilbenoid found in grapes and berries known for its anti-inflammatory effects. It inhibits the STAT3 signaling pathway, which can regulate LCE3B expression. By targeting STAT3, resveratrol may result in the functional inhibition of LCE3B by decreasing its expression in epidermal cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is an isothiocyanate found in cruciferous vegetables, known for its ability to influence genetic expression. It inhibits histone deacetylase enzymes, which can lead to the suppression of LCE3B expression by altering chromatin structure and thus inhibiting its functional activity. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
Indirubin is a derivative of indigo with kinase inhibitory activity. It targets GSK-3β, a kinase involved in the regulation of various genes, potentially including LCE3B. By inhibiting GSK-3β, indirubin may lead to the downregulation of LCE3B expression, indirectly inhibiting its function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. It modulates the JNK signaling pathway, which may be involved in the regulation of LCE3B expression. By inhibiting JNK, quercetin can result in decreased expression of LCE3B, thus leading to its functional inhibition. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavone found in many fruits and vegetables that exhibits anti-inflammatory and antioxidant effects. It inhibits the PI3K/Akt pathway, which may be involved in the control of LCE3B expression. By dampening PI3K/Akt signaling, apigenin can decrease LCE3B expression, resulting in functional inhibition. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is a flavonol with anti-inflammatory and antioxidant effects. It can inhibit ERK1/2 signaling, which might be implicated in the regulation of LCE3B. By targeting ERK1/2, kaempferol can lead to the downregulation of LCE3B expression and its functional inhibition. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic acid is a hydroxycinnamic acid with antioxidant properties. It interferes with NF-κB signaling, which can lead to the downregulation of LCE3B expression. By modulating this pathway, caffeic acid can diminish the functional activity of LCE3B. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy products with kinase inhibitory activity. It can modulate estrogen receptor signaling, which may affect the expression of LCE3B. By influencing this pathway, genistein can lead to the decreased expression and functional inhibition of LCE3B. | ||||||