KRTAP5-4 Inhibitors
KRTAP5-4 inhibitors are an array of chemical compounds that interfere with the cellular and molecular pathways essential for the proper functioning of KRTAP5-4. Cycloheximide is a profound inhibitor of protein synthesis, which can substantially reduce the production of KRTAP5-4 by halting the elongation step in protein synthesis on ribosomes. MG-132 is a proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins, which may sequester KRTAP5-4 and prevent it from performing its role. Actinomycin D suppresses mRNA synthesis by binding with DNA, indirectly leading to a decrease in the availability of KRTAP5-4. Staurosporine, being a broad-spectrum kinase inhibitor, has the potential to alter phosphorylation patterns of proteins that are required for the functional regulation of KRTAP5-4.
Further disrupting KRTAP5-4 functionality are compounds like Chloroquine, which by increasing lysosomal pH, could interfere with the post-translational processing of KRTAP5-4, while Brefeldin A could result in the misfolding and subsequent degradation of KRTAP5-4 by inhibiting its transport to the Golgi apparatus. Calyculin A affects protein phosphorylation dynamics, potentially altering KRTAP5-4 interactions and function within keratinocytes. In the cell cycle context, Alsterpaullone serves as a cyclin-dependent kinase inhibitor, which can influence the cellular context in which KRTAP5-4 operates, particularly affecting cells undergoing proliferation or differentiation. Gö6976 reduces protein kinase C (PKC) activity, impacting signaling pathways that might regulate KRTAP5-4 function. Geldanamycin destabilizes proteins by inhibiting Hsp90, affecting protein complexes that KRTAP5-4 may be part of.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Protein synthesis inhibitor that blocks the translocation step in protein synthesis on the ribosome, leading to reduced synthesis of many proteins including KRTAP5-4. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially causing a buildup of proteins that can sequester KRTAP5-4, limiting its functional availability. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Transcription inhibitor that binds to DNA and prevents the transcription of mRNA; by inhibiting mRNA synthesis, it indirectly decreases the production of KRTAP5-4. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can inhibit a wide range of protein kinases, potential affecting the phosphorylation status of proteins that interact with or regulate KRTAP5-4. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Lysosomotropic agent that raises lysosomal pH, potentially affecting the post-translational modification of KRTAP5-4 by inhibiting lysosome-dependent processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Inhibitor of protein transport from the endoplasmic reticulum to the Golgi apparatus, which could lead to misfolding and degradation of KRTAP5-4 before it reaches its functional location. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Serine/threonine phosphatase inhibitor that can alter the phosphorylation state of proteins in keratinocytes, potentially modifying the interaction and function of KRTAP5-4 in hair follicles. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Cyclin-dependent kinase inhibitor that can disrupt cell cycle progression and potentially affect the proliferation or differentiation of cells expressing KRTAP5-4. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
PKC inhibitor that may reduce the phosphorylation and activity of proteins involved in the signaling pathways that regulate the function of KRTAP5-4. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Hsp90 inhibitor that can destabilize client proteins and lead to their degradation, potentially affecting protein complexes involving KRTAP5-4. | ||||||