Krs-1 Activators
KRS-1 Activators encompass a collection of chemical compounds that enhance the functional activity of KRS-1 by impinging on various specific signaling pathways. Forskolin acts by increasing intracellular cAMP, which in turn activates PKA; this kinase can phosphorylate targets that amplify KRS-1's activity through conformational changes or increased substrate affinity. Similarly, Ionomycin, by elevating intracellular calcium levels, can initiate a cascade involving CaMKs, which may phosphorylate and hence enhance KRS-1 activity. KRS-1 Activators encompass a collection of chemical compounds that enhance the functional activity of KRS-1 by impinging on various specific signaling pathways. Forskolin acts by increasing intracellular cAMP, which in turn activates PKA; this kinase can phosphorylate targets that amplify KRS-1's activity through conformational changes or increased substrate affinity. Similarly, Ionomycin, by elevating intracellular calcium levels, can initiate a cascade involving CaMKs, which may phosphorylate and hence enhance KRS-1 activity. PMA, a PKC activator, and IBMX, a phosphodiesterase inhibitor, both promote the phosphorylation of KRS-1, potentially augmenting its catalytic efficiency.
Krs-1 Activators represent an intriguing chemical class designed to modulate the activity of a specific target, known as Krs-1, which is implicated in a range of cellular processes. These molecules can enhance the function of Krs-1 through various biochemical mechanisms. For instance, some activators in this class can act as allosteric modulators, binding to regions of the Krs-1 protein distinct from the active site, inducing a conformational change that increases the protein's intrinsic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA. PKA then phosphorylates specific targets that can lead to the activation of KRS-1 by enhancing its substrate affinity or altering its conformation for better functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, elevating intracellular calcium levels. Elevated calcium can activate calcium/calmodulin-dependent protein kinases (CaMKs), which could enhance the phosphorylation state of KRS-1, thereby increasing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activated PKC can phosphorylate specific serine/threonine residues on KRS-1, which may increase its catalytic activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to an increase in cAMP levels. Elevated cAMP can activate PKA, which could then phosphorylate and activate KRS-1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit certain protein kinases, which might remove inhibitory phosphorylations on KRS-1 or on proteins that modulate KRS-1 activity, thereby enhancing its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K. By inhibiting PI3K, the downstream signaling involving Akt is modulated, potentially leading to an increase in KRS-1 activity by reducing negative feedback loops. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate engages with its receptors to activate signaling pathways that can lead to the activation of KRS-1 through enhanced protein-protein interactions that promote KRS-1's function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Although staurosporine is a broad-spectrum kinase inhibitor, it can lead to selective activation of KRS-1 by inhibiting kinases that normally phosphorylate inhibitory sites on KRS-1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases 1 and 2A, which could lead to an increased phosphorylation state of KRS-1, enhancing its activity due to reduced dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases, potentially leading to the phosphorylation and activation of KRS-1 within the stress response pathway. | ||||||