KLHL20 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Since KLHL20 is involved in protein ubiquitination, MG132 indirectly leads to an accumulation of KLHL20 substrates, thus functionally diminishing the apparent activity of KLHL20 by reducing its availability to ubiquitinate additional substrates. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
A NEDD8-activating enzyme inhibitor that impairs the neddylation process. Neddylation is essential for the activity of cullin-RING ligases (CRLs), to which KLHL20 belongs. Inhibition of neddylation by MLN4924 could lead to a decrease in the ubiquitin ligase activity of KLHL20. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound that inhibits the NF-κB pathway, which can regulate the expression of multiple genes including KLHL20. By inhibiting this pathway, curcumin could diminish the transcriptional levels of KLHL20, leading to a reduction in its protein levels and thus its activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
An autophagy inhibitor that can increase the cellular levels of p62, a selective substrate for autophagic degradation. Since KLHL20 promotes the degradation of p62, inhibition of autophagy by chloroquine could lead to the accumulation of p62 and a subsequent decrease in the degradation activity of KLHL20. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor similar to MG132, which can diminish the degradation of ubiquitinated proteins. By doing so, bortezomib could indirectly diminish the functional activity of KLHL20 by causing an accumulation of its substrates within the cell. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
A cereblon modulator that can affect the activity of cullin-RING E3 ubiquitin ligases. Since KLHL20 is part of this family, thalidomide might affect the ligase activity of KLHL20 by modulating the substrate recognition component of the ligase complex. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Another proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins, which is expected to indirectly decrease the catalytic turnover of KLHL20 by rendering its substrates less accessible for ubiquitination and subsequent degradation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A compound that influences gene expression through retinoic acid receptors. It can alter the expression of genes involved in the ubiquitination pathway, potentially leading to a decrease in the functional activity of KLHL20 by affecting its expression or the availability of its substrates. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $81.00 $183.00 | 34 | |
An estrogen receptor degrader that can also affect the expression of various proteins including those in the ubiquitin-proteasome system. By altering the expression of these proteins, fulvestrant may indirectly diminish the functional activity of KLHL20. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that could lead to diminished degradation of KLHL20 substrates, thereby indirectly decreasing the activity of KLHL20 by causing a substrate backlog. | ||||||