Kin28 Inhibitors
Several inhibitors can target Kin28 by inhibiting its associated cyclin-dependent kinase (CDK) activity. One such inhibitor is DRB. DRB acts as a competitive inhibitor of CDK7, which forms a complex with Kin28 in the TFIIH complex. By binding to CDK7, DRB prevents its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. Flavopiridol is another CDK inhibitor that can target Kin28. It acts as a broad-spectrum CDK inhibitor, blocking the activity of multiple CDKs, including CDK7. By inhibiting CDK7, Flavopiridol prevents the activation and phosphorylation of Kin28, thereby inhibiting its function in transcriptional regulation. Roscovitine and THZ1 are selective inhibitors of CDK7 that can also inhibit Kin28. They bind to CDK7 and prevent its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation.
Other CDK inhibitors, such as Dinaciclib, SNS-032, AZD 5438, AT7519, and Cdc7/Cdk9 Inhibitor, can also target CDK7 and inhibit Kin28 by blocking its phosphorylation and transcriptional regulatory functions. Lastly, Aurora Kinase/Cdk Inhibitor is a selective inhibitor of CDK7 that can inhibit Kin28 by preventing its activation and phosphorylation. In summary, Kin28 inhibitors primarily target the CDK activity associated with Kin28, disrupting its phosphorylation and transcriptional regulatory functions. These inhibitors can potentially be used to study the role of Kin28 in transcriptional regulation and explore its potential implications in diseases where dysregulated gene expression is involved.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is a synthetic compound that can inhibit Kin28 by targeting the cyclin-dependent kinase (CDK) activity. It acts as a competitive inhibitor of CDK7, which forms a complex with Kin28 in the TFIIH complex. By binding to CDK7, DRB prevents its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a broad-spectrum CDK inhibitor, blocking the activity of multiple CDKs, including the CDK7 component of the TFIIH complex. By inhibiting CDK7, Flavopiridol prevents the activation and phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a selective inhibitor of CDK7, which forms a complex with Kin28 in the TFIIH complex. By binding to CDK7, Roscovitine prevents its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
THZ1 is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a selective inhibitor of CDK7, which forms a complex with Kin28 in the TFIIH complex. By binding to CDK7, THZ1 prevents its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a broad-spectrum CDK inhibitor, blocking the activity of multiple CDKs, including CDK7. By inhibiting CDK7, Dinaciclib prevents the activation and phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a selective inhibitor of CDK7, which forms a complex with Kin28 in the TFIIH complex. By binding to CDK7, SNS-032 prevents its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD 5438 is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a broad-spectrum CDK inhibitor, blocking the activity of multiple CDKs, including CDK7. By inhibiting CDK7, AZD 5438 prevents the activation and phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
AT7519 | 844442-38-2 | sc-364416 sc-364416A sc-364416B sc-364416C | 5 mg 10 mg 100 mg 1 g | $207.00 $246.00 $1025.00 $3065.00 | 1 | |
AT7519 is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a broad-spectrum CDK inhibitor, blocking the activity of multiple CDKs, including CDK7. By inhibiting CDK7, AT7519 prevents the activation and phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
Cdc7/Cdk9 Inhibitor | 845714-00-3 | sc-311303 | 5 mg | $270.00 | 1 | |
Cdc7/Cdk9 Inhibitor is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a selective inhibitor of CDK7, which forms a complex with Kin28 in the TFIIH complex. By binding to CDK7, Cdc7/Cdk9 Inhibitor prevents its activation and subsequent phosphorylation of Kin28, leading to the inhibition of Kin28-mediated phosphorylation and transcriptional regulation. | ||||||
Aurora Kinase/Cdk Inhibitor | 443797-96-4 | sc-203829 | 5 mg | $440.00 | ||
Aurora Kinase/Cdk Inhibitor is a synthetic compound that can inhibit Kin28 by targeting the CDK activity. It acts as a selective inhibitor of CDK7, which forms a complex withKin28 is a protein that plays a crucial role in transcriptional regulation as a component of the TFIIH complex. TFIIH is involved in the initiation of transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II and facilitating the recruitment of other transcription factors. Inhibition of Kin28 can disrupt this process and affect gene expression. | ||||||