KIF1A Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a cell-permeable small molecule inhibitor that specifically targets the motor protein Eg5, a kinesin-like protein related to KIF1A. It inhibits Eg5 by inducing a monoastral spindle formation, which can indirectly affect KIF1A's function in cell division and vesicle transport. | ||||||
Eg5 Inhibitor III, Dimethylenastron | 863774-58-7 | sc-221576 sc-221576A sc-221576B sc-221576C | 1 mg 5 mg 10 mg 25 mg | $38.00 $132.00 $244.00 $516.00 | 1 | |
Dimethylenastron is an Eg5 kinesin inhibitor. It impedes the ATPase activity of Eg5, thereby interfering with the mitotic spindle dynamics. This indirect inhibition can affect KIF1A related pathways by altering cellular transport mechanisms during cell division. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $495.00 | ||
Ispinesib is a selective inhibitor of Kinesin Spindle Protein (KSP), which is closely related to KIF1A. By inhibiting KSP, ispinesib disrupts microtubule dynamics, potentially influencing KIF1A's function in neuronal transport. | ||||||
(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide | 885060-09-3 | sc-479542 | 10 mg | $430.00 | ||
(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide, also known as Filanesib, is a selective KSP inhibitor. It binds to KSP at the allosteric site, blocking its activity and affecting microtubule stability. This can indirectly influence KIF1A functions in neurons. | ||||||
K 858 | 72926-24-0 | sc-300856 sc-300856A | 10 mg 50 mg | $159.00 $693.00 | ||
K 858 is a selective and potent Eg5 inhibitor. It targets the motor domain of Eg5, leading to an inhibition of its ATPase activity. This can indirectly modulate KIF1A-related pathways in neuronal transport. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a potent inhibitor of Eg5. It acts by blocking the ATP binding site, leading to a halt in the motor activity of Eg5 and potentially influencing KIF1A's functions. | ||||||
trans-HR22C16 | 462630-41-7 | sc-202842 | 1 mg | $128.00 | ||
HR22C16 is an inhibitor of Eg5. It specifically targets the loop 5 site of Eg5, distinct from the ATP-binding site, leading to an indirect modulation of KIF1A-associated pathways. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI-2536 is a potent Plk1 inhibitor. By inhibiting Plk1, it disrupts spindle formation and can indirectly impact KIF1A-related functions in neurons. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
GSK923295 is a selective inhibitor of CENP-E motor protein, which is involved in chromosome alignment. This can influence KIF1A indirectly by affecting cellular transport processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor. By inhibiting Aurora kinases, it affects spindle assembly and chromosome segregation, potentially impacting KIF1A-related pathways. | ||||||