KIAA0776 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the KIAA0776 protein, also known as C3orf52 or Fam201a. This protein, encoded by the KIAA0776 gene, is relatively understudied but is believed to play a role in various cellular processes, including intracellular trafficking, membrane dynamics, and possibly signal transduction pathways. The development of inhibitors for KIAA0776 stems from the need to elucidate its precise functions within the cell and explore potential applications in biotechnology and basic research.
Chemically, KIAA0776 inhibitors can vary widely, encompassing small molecules or biologics that can selectively bind to the KIAA0776 protein, thereby inhibiting its normal activity. These inhibitors are typically designed with the aim of disrupting the protein's function, either by blocking its active site or interfering with its interaction with other cellular components. The discovery and design of KIAA0776 inhibitors often involve high-throughput screening, structure-based drug design, or other molecular modeling techniques to identify compounds with the desired inhibitory properties. Subsequent testing and optimization help refine these inhibitors for research purposes, shedding light on the protein's role in cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Induces Nrf2 by modifying KEAP1 cysteine residues, disrupting the KEAP1-Nrf2 interaction. | ||||||
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
Binds to cysteine residues on KEAP1, modulating the Nrf2 pathway. | ||||||
Brusatol | 14907-98-3 | sc-507427 | 5 mg | $148.00 | 1 | |
Enhances the degradation of Nrf2, indirectly affecting KEAP1's regulatory role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates Nrf2 activity by disrupting its interaction with KEAP1. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Modifies cysteine residues on KEAP1, leading to Nrf2 accumulation and activation. | ||||||
CDDO Methyl Ester | 218600-53-4 | sc-504720 | 10 mg | $220.00 | ||
Forms adducts with KEAP1 cysteine residues, promoting Nrf2 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences the Nrf2 pathway and may indirectly affect KEAP1's function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Has been shown to disrupt KEAP1-Nrf2 interaction, consequently enhancing Nrf2 signaling. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
Electrophilic compound that can modify KEAP1, leading to Nrf2 activation. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Modifies KEAP1 cysteine residues, resulting in Nrf2 pathway activation. | ||||||