KIAA0701 Activators
Chemical activators of KIAA0701 can initiate a cascade of intracellular events leading to the protein's functional activation. Phorbol 12-myristate 13-acetate (PMA), for instance, activates protein kinase C (PKC), which is adept at phosphorylating target proteins, including KIAA0701. This phosphorylation typically results in a conformational change that can increase the protein's activity. Forskolin, by elevating cAMP levels, activates protein kinase A (PKA), another kinase capable of phosphorylating KIAA0701, ensuring its activation. Similarly, 8-Bromo-cAMP, a cAMP analog, also activates PKA, which in turn can phosphorylate and activate KIAA0701. Anisomycin triggers the MAPK signaling pathways which can lead to the activation of KIAA0701 through phosphorylation. In parallel, Epigallocatechin gallate (EGCG) activates AMP-activated protein kinase (AMPK), a kinase that can also phosphorylate and activate KIAA0701.
The intracellular calcium ion concentration is pivotal for the activation of calcium-dependent kinases that can phosphorylate KIAA0701. Chemicals like Ionomycin and Thapsigargin disrupt calcium homeostasis, leading to the activation of such kinases. Ionomycin directly raises intracellular calcium levels, while Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), causing a rise in cytosolic calcium levels. Both pathways can lead to the phosphorylation and activation of KIAA0701. On the other hand, Okadaic Acid and Calyculin A prevent the dephosphorylation of KIAA0701 by inhibiting protein phosphatases PP1 and PP2A, thereby sustaining KIAA0701 in an active state. Bisindolylmaleimide I, though typically a PKC inhibitor, can paradoxically induce the activation of PKC isoforms that might phosphorylate KIAA0701 under certain conditions. Furthermore, signaling molecules like Hydrogen Peroxide can modulate kinase activity, leading to the activation of KIAA0701. Lastly, Zinc Chloride can influence the activity of kinases and phosphatases, thereby promoting the phosphorylation and subsequent activation of KIAA0701 through its modulation of kinase activity. Each of these chemicals orchestrates a unique molecular dialogue within the cell that culminates in the activation of KIAA0701.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which is known to phosphorylate a wide range of target proteins. KIAA0701 can be phosphorylated by PKC, leading to its functional activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels, which in turn activate PKA. PKA can phosphorylate KIAA0701, thereby activating it. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin raises intracellular calcium levels, which can activate calcium-dependent protein kinases that may phosphorylate and thus activate KIAA0701. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of proteins. This inhibition can result in the sustained activation of KIAA0701 by preventing its dephosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits protein phosphatases, particularly PP1 and PP2A, which could keep KIAA0701 in a phosphorylated and active state. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA then can phosphorylate KIAA0701, resulting in its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates MAPK signaling pathways which can lead to the phosphorylation and activation of several proteins. Through these pathways, KIAA0701 can be phosphorylated and activated. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can activate AMP-activated protein kinase (AMPK). Activated AMPK has been known to phosphorylate various downstream proteins, potentially including KIAA0701, leading to its activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels, which could activate calcium-sensitive kinases that phosphorylate KIAA0701. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC, but it can also serve as an activator under certain conditions by inducing the translocation and activation of PKC isoforms that could phosphorylate KIAA0701. | ||||||