Ki-67 Activators
Ki-67 Activators refers to a class of chemical compounds that can increase the expression or activity of the Ki-67 protein. Ki-67 is a protein that serves as a cellular marker for proliferation. It is expressed in all active phases of the cell cycle-G1, S, G2, and mitosis-but is notably absent in quiescent or resting (G0) cells. Initially identified in Hodgkin's lymphoma cells, the protein got its name as it was the 67th antigenic protein identified by the monoclonal antibody "Kiel." Ki-67 is often used in biological research and pathology as an indicator of cell proliferation. Its expression is used to assess the growth fraction of various cell populations, especially in situations where understanding the rate of cell division is crucial, such as in rapidly dividing populations.
The chemical class of Ki-67 Activators includes a wide range of molecules that can induce the expression of the Ki-67 protein. These could be hormones like estradiol and testosterone, metabolites like retinoic acid, or even other small molecules like forskolin and resveratrol. The primary role of these activators is to stimulate cellular processes that lead to cell proliferation. This is often achieved through a variety of mechanisms, such as activation of specific signaling pathways or transcription factors that subsequently lead to increased Ki-67 expression. These compounds can serve as invaluable tools for researchers studying cell cycle dynamics, cellular aging, and mechanisms of cell division. Importantly, while these activators induce the expression of Ki-67, their specific mechanisms of action can vary widely, offering a rich area of study for those interested in the complex regulation of cell proliferation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol is a female sex hormone that has been shown to induce cell proliferation in certain tissues, such as breast tissue. Increased cell proliferation correlates with an increase in the expression of Ki-67. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A and plays a crucial role in cell differentiation and growth. It has been observed to upregulate Ki-67 in certain cell lines. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that activates adenylate cyclase, leading to increased cAMP levels and hence cell proliferation. This often correlates with increased Ki-67 levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes. It has been shown to induce cell proliferation in certain cell types, leading to an increase in Ki-67 expression. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone is a corticosteroid hormone that may stimulate cell proliferation in some tissues. This can be correlated with increased levels of Ki-67. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a phytoestrogen and has been observed to induce cell proliferation in specific cell types, thereby increasing the expression of Ki-67. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a catecholamine that can stimulate cell proliferation in tissues like the adrenal medulla, which correlates with an increase in Ki-67 levels. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride has been used to study cell proliferation and differentiation. It has been shown to increase Ki-67 expression in specific cell types. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine is an amino sulfonic acid that can induce cell proliferation in certain tissues, leading to elevated levels of Ki-67. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that has been observed to induce cell proliferation in some instances, thereby leading to increased Ki-67 expression. | ||||||