Keratin 73 Inhibitors

Chemical inhibitors of Keratin 73 can exert their inhibitory effects through various biochemical interactions that disrupt the protein's structure and function. Acrylamide, for instance, can form covalent adducts with cysteine residues within Keratin 73, altering disulfide bonding and thus impeding the protein's proper tertiary and quaternary structure formation. This results in a diminished structural integrity crucial for its function within hair fibers. Similarly, Lead Acetate can bind to the thiol groups present in Keratin 73, inducing conformational changes that compromise the protein's stability and functionality. Malachite Green, known for its ability to intercalate within protein structures, can interfere with the intricate fibril arrangements of Keratin 73, leading to destabilization and functional impairment of the protein's fibrous architecture. Formaldehyde, by cross-linking amino groups, can inhibit Keratin 73 by preventing the proper fibrous assembly, which is essential for its mechanical strength and structural role in hair. On the other hand, chemicals such as Trichloroacetic Acid can precipitate Keratin 73 by denaturing it, thereby inhibiting its structural functionality as a fibrous protein. Phenol can similarly denature Keratin 73 by disrupting hydrogen bonds and disulfide bridges, leading to a loss of its three-dimensional structure and consequent functional inhibition. Hydroxylamine alters the protein's structure by modifying asparagine and glutamine residues, which can have a direct impact on the structural functionality of Keratin 73. Similarly, Urea can unfold the protein structure of Keratin 73 through the disruption of hydrogen bonds, inhibiting its ability to form the proper fibrous network. Chemicals like SDS (Sodium Dodecyl Sulfate) can solubilize and denature Keratin 73, preventing correct assembly and function. Mercury(II) chloride and Silver Nitrate can both interact with thiol groups within Keratin 73, forming complexes that inhibit the protein's structural and functional integrity. Cadmium Chloride may bind to Keratin 73 and displace essential metal ions or directly interact with the protein, leading to a loss of functional conformation and thus inhibiting its role within the hair shaft.