Keratin 39 Activators
Epidermal Growth Factor (EGF), known for its role in skin biology, binds to surface receptors that activate MAPK and PI3K/AKT, signaling cascades critical to keratin regulation. Calcitriol, the bioactive form of vitamin D, can modulate gene expression via its receptor, potentially altering keratin synthesis. Inflammatory mediators such as Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1 (IL-1), and Interferon-gamma (IFN-γ) can induce transcription factors like NF-κB, influencing keratin gene expression as part of the inflammatory response. Similarly, Transforming Growth Factor-beta (TGF-β) has a role in cellular differentiation, which may extend to keratin expression adjustments.
Forskolin, with its capacity to elevate cAMP, affects signaling pathways that could lead to keratin gene modulation. Lithium Chloride impacts the Wnt/β-catenin pathway, a known influence on gene expression profiles, including keratins. Methyl Jasmonate has been shown to affect pathways that could also influence keratin expression. Dexamethasone leverages glucocorticoid receptors to effect gene expression changes, encompassing keratin genes. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C, which may lead to transcriptional shifts affecting keratin expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Interacts with retinoic acid receptors altering gene expression, possibly affecting KRT39 expression. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Binds to the vitamin D receptor, potentially influencing the expression of various keratins including KRT39. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
Regulates cell differentiation and may influence keratin expression patterns. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences Wnt/β-catenin pathway, potentially affecting keratin expression. | ||||||
(±)-Methyl Jasmonate | 39924-52-2 | sc-205386 sc-205386A sc-205386B sc-205386C sc-205386D sc-205386E sc-205386F | 1 g 5 g 10 g 50 g 100 g 500 g 1 kg | $36.00 $105.00 $204.00 $890.00 $1671.00 $7081.00 $12491.00 | ||
Affects signaling pathways and gene expression profiles including those related to keratins. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Acts on glucocorticoid receptors modulating gene expression, which may include keratin genes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C which can lead to changes in the expression of keratin genes. | ||||||