KCTD5 Activators
KCTD5 Activators are chemicals known to activate KCTD5, largely by indirectly influencing cellular stress pathways that result in increased ubiquitination. Agents like Sodium Arsenite and Hydrogen Peroxide induce oxidative stress, which naturally leads to increased ubiquitination. The ubiquitin-proteasome pathway, where KCTD5 plays a role, becomes more active as a result. Other agents like Zinc Chloride and Cadmium Chloride are known to increase ubiquitination due to cellular stress. These chemicals do not inhibit the proteasome or other degradation pathways; they primarily increase the pool of ubiquitinated proteins, demanding more activity from KCTD5.
Likewise, compounds such as Sodium Orthovanadate and Sodium Fluoride induce cellular stress by inhibiting enzymatic activity, leading to increased ubiquitination and subsequent activation of KCTD5. These activators specifically increase the need for KCTD5 without inhibiting its function or the function of the proteasome. Thus, they are well-positioned to serve as KCTD5 activators based on current biochemical understanding.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Induces oxidative stress, causing increased ubiquitination and thereby activating KCTD5 to facilitate proteasome degradation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Enhances ubiquitin conjugation to proteins, subsequently activating KCTD5 by increasing substrate availability. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Causes cellular stress and increases ubiquitination of stress-responsive proteins, thereby necessitating KCTD5 activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Inhibits phosphatases, which may lead to increased ubiquitination and thus increased demand for KCTD5. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Induces ER stress and enhances ubiquitination, indirectly leading to increased KCTD5 activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Induces oxidative stress, thereby increasing the number of ubiquitinated proteins requiring KCTD5 for degradation. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Causes nitrosative stress, leading to increased ubiquitination and hence more substrate for KCTD5 activity. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Causes oxidative stress, leading to an increase in ubiquitination, thereby activating KCTD5. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Inhibits several enzymes, causing stress and increased ubiquitination, which activates KCTD5. | ||||||