KCTD11 Activators
KCTD11 activators constitute a group of compounds that interact with various cellular pathways to modulate the activity of KCTD11, a protein involved in diverse cellular functions. These chemicals, such as lithium chloride and sodium valproate, activate the WNT signaling pathway, which indirectly impacts KCTD11 by influencing its interaction with this pathway.
Similarly,XAV939 indirectly activate KCTD11 by inhibiting the WNT signaling pathway and promoting ciliogenesis, a crucial process for cilia formation and function. N-acetyl-L-cysteine reduces oxidative stress and supports ciliogenesis, indirectly enhancing KCTD11 function. Furthermore, natural compounds like curcumin and resveratrol activate KCTD11 by reducing oxidative stress, promoting ciliogenesis, and stimulating pathways like SIRT1. Metformin and rapamycin activate KCTD11 via the AMPK and mTOR pathways, respectively, both of which play roles in regulating ciliogenesis. Additionally, forskolin directly activates KCTD11 by increasing cAMP levels and activating the PKA pathway, which interacts with KCTD11. Nifedipine indirectly activates KCTD11 by elevating intracellular calcium levels, while BAY K 8644 directly does so by further increasing intracellular calcium levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Mood stabilizer that activates the WNT signaling pathway, which has been shown to interact with KCTD11. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Anticonvulsant that can also activate the WNT signaling pathway. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Tankyrase inhibitor that can indirectly activate KCTD11 by inhibiting the WNT signaling pathway and promoting ciliogenesis. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
Glutathione precursor that can activate KCTD11 by reducing oxidative stress and promoting ciliogenesis. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Biguanide used to treat type 2 diabetes that can activate KCTD11 by activating the AMPK pathway, which has been shown to promote ciliogenesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that can activate KCTD11 by inhibiting the mTOR pathway, which has been shown to promote ciliogenesis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Direct activator of adenylate cyclase that can increase cAMP levels and activate the PKA pathway, which has been shown to interact with KCTD11. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
L-type calcium channel blocker that can indirectly activate KCTD11 by increasing intracellular calcium levels, which has been shown to promote ciliogenesis. | ||||||