KCNV1 Activators
KCNV1 Activators encompass a diverse set of chemical compounds that, through their individual actions, can enhance the functional activity of the KCNV1 protein, which is a modulatory subunit of voltage-gated potassium channels. These activators, including Retigabine and Flupirtine, facilitate the opening of potassium channels, subsequently supporting the role of KCNV1 in fine-tuning the electrical properties of neurons. The function of KCNV1 is crucial in the modulation of the neuronal resting membrane potential and action potential repolarization, and theseactivators are essential for influencing the neuronal excitability and overall neurological function.
The compounds targeting KCNV1, have mechanisms of action that may result in an increased activity of the channels that KCNV1 modulates. This could lead to more stabilized neuronal firing rates, which is particularly beneficial in various neurological disorders where dysregulation of ion channels contributes to disease pathology. Activators such as Zinc Pyrithione and Bithionol may indirectly enhance KCNV1's activity by modifying the biophysical properties of associated channels, leading to increased potassium ion conductance and improved neuronal function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione is known to increase the activity of certain voltage-gated potassium channels. By binding to modulatory sites, it can enhance the functional activity of KCNV1 by stabilizing the open conformation of the channel complex, allowing for increased potassium flux. | ||||||
Flupirtine Maleate | 75507-68-5 | sc-218512 | 10 mg | $103.00 | 1 | |
Flupirtine is a selective neuronal potassium channel opener that can enhance the activity of KCNV1-associated channel complexes. By promoting the opening of these channels, flupirtine leads to hyperpolarization of the neuronal membrane, which can indirectly increase the activity of KCNV1 as it participates in setting the resting membrane potential. | ||||||
Bithionol | 97-18-7 | sc-239383 | 25 g | $79.00 | ||
Bithionol potentizes voltage-gated potassium channels by altering their voltage-sensitivity. This action can lead to an indirect enhancement of KCNV1's modulatory effect on the channel complex, increasing potassium conductance. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $193.00 $213.00 $317.00 | 1 | |
Riluzole modulates neuronal excitability by enhancing the activity of voltage-gated potassium channels. This enhancement can, in turn, amplify the function of KCNV1, which modulates the properties of these channels. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
Amiodarone affects potassium channels by altering their kinetics and increasing their open probability, which can lead to the enhancement of KCNV1's modulatory role in these channels. | ||||||
Pinacidil monohydrate | 85371-64-8 | sc-203198 sc-203198A | 10 mg 50 mg | $51.00 $95.00 | 6 | |
Pinacidil opens ATP-sensitive potassium channels, which can have a downstream effect on the modulation of voltage-gated potassium channels involving KCNV1, enhancing the current flow through these channels. | ||||||
Nicorandil | 65141-46-0 | sc-200995 sc-200995B sc-200995A sc-200995C | 50 mg 100 mg 250 mg 1 g | $57.00 $98.00 $240.00 $500.00 | 4 | |
Nicorandil activates ATP-sensitive potassium channels and, by doing so, can enhance the activity of voltage-gated potassium channels modulated by KCNV1, leading to an increased potassium current. | ||||||
PD-118057 | 313674-97-4 | sc-253238 | 5 mg | $215.00 | ||
PD-118057 targets and enhances ether-a-go-go-related gene (hERG) potassium channels. This enhancement can indirectly affect the modulation of KCNV1 on the electrical properties of cells by influencing the overall potassium channel activity. | ||||||