KCNMB4 Inhibitors
KCNMB4 inhibitors belong to a specialized class of chemical compounds designed to target the KCNMB4 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4) protein. KCNMB4 is a member of the KCNMB family of proteins, which are associated with calcium-activated potassium channels, specifically BK (big conductance) channels. These channels play crucial roles in regulating membrane calcium homeostasis in various cell types, including neurons, smooth muscle cells, and some epithelial cells. KCNMB4, as a regulatory subunit, is known to modulate the activity and properties of BK channels, influencing their conductance and calcium sensitivity.
Inhibitors of KCNMB4 are designed to interact with the protein and modulate its influence on BK channel function. The precise mechanisms by which these inhibitors achieve this modulation are areas of ongoing research. By targeting KCNMB4, these compounds can affect the biophysical properties of BK channels, thereby altering cellular excitability, muscle contractility, and calcium signaling. Research on KCNMB4 inhibitors is primarily focused on elucidating the molecular mechanisms by which KCNMB4 regulates BK channels and its impact on cellular physiology, contributing to our understanding of ion channel function and calcium-mediated signaling in various tissues and cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into DNA and RNA, leading to hypomethylation of DNA which may indirectly affect KCNMB4 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, which changes chromatin structure and could potentially alter KCNMB4 gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A short-chain fatty acid that acts as a histone deacetylase inhibitor, possibly affecting KCNMB4 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Another DNA methyltransferase inhibitor, which could lead to gene reactivation, potentially influencing KCNMB4 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that could affect the transcription of numerous genes, including KCNMB4. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A DNA methyltransferase inhibitor, potentially reducing methylation and affecting KCNMB4 expression. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
A histone deacetylase inhibitor which may have an indirect effect on KCNMB4 gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
The main catechin in green tea, known to affect DNA methylation and histone acetylation, could influence KCNMB4 expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective histone deacetylase inhibitor that can alter gene expression, possibly including KCNMB4. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A well-known histone deacetylase inhibitor that can affect gene expression, potentially altering KCNMB4 levels. | ||||||