karyopherin α6 Activators
Karyopherin α6 activators, in the context of this discussion, largely comprise chemicals that influence the protein indirectly. These activators are diverse in their mechanisms, affecting various cellular processes and signaling pathways that can modulate the function of KPNA6, especially in its role in nuclear import. The list includes inhibitors of specific proteins like exportin 1 and importin α/β1, as well as broader pathway modulators like mTOR inhibitors and PI3K inhibitors.
The first paragraph of this description should typically elucidate the general role of KPNA6 and the indirect mechanism through which these activators operate. Karyopherin α6 is integral to the nuclear import of proteins, a process essential for maintaining cellular function and response to external stimuli. The activators listed, while not directly targeting KPNA6, influence its activity by modifying the nuclear-cytoplasmic transport equilibrium, either by inhibiting competing pathways (like CRM1-dependent nuclear export) or by altering cellular states that indirectly enhance KPNA6-mediated import. For instance, Leptomycin B, by inhibiting exportin 1, could shift the balance towards nuclear import, potentially amplifying KPNA6's role.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates karyopherin α6 by inhibiting the activity of SIRT1, a deacetylase that negatively regulates karyopherin α6 function. This inhibition leads to increased acetylation and subsequent activation of karyopherin α6, promoting nuclear import processes. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Directly activates karyopherin α6 by binding to its nuclear export signal (NES) binding pocket, thereby preventing the formation of karyopherin α6-export cargo complexes. This inhibition of export complexes promotes the nuclear retention and functional activation of karyopherin α6, facilitating nuclear import events. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Indirectly activates karyopherin α6 by inhibiting the activity of tyrosine kinases, such as EGFR and Src, which phosphorylate karyopherin α6 and regulate its nuclear import function. By inhibiting these kinases, genistein promotes the dephosphorylation and subsequent activation of karyopherin α6, facilitating efficient nuclear import processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Activates karyopherin α6 by modulating the activity of MAPK signaling pathways, specifically ERK and JNK, which phosphorylate karyopherin α6 and regulate its nuclear import function. By inhibiting these kinases, EGCG promotes the dephosphorylation and subsequent activation of karyopherin α6, facilitating efficient nuclear import processes. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Directly activates karyopherin α6 by inhibiting the activity of protein tyrosine phosphatases (PTPs), which dephosphorylate and inactivate karyopherin α6. By blocking PTP activity, sodium orthovanadate promotes the sustained phosphorylation and functional activation of karyopherin α6, enhancing its nuclear import capacity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Indirectly activates karyopherin α6 by modulating the activity of NF-κB signaling pathways, which regulate the expression and phosphorylation status of karyopherin α6. By inhibiting NF-κB activation, curcumin promotes the upregulation and phosphorylation-dependent activation of karyopherin α6, facilitating efficient nuclear import processes. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Indirectly activates karyopherin α6 by inhibiting the activity of topoisomerase I, which regulates DNA topology and transcriptional activity. By inhibiting topoisomerase I, camptothecin promotes the stabilization and nuclear accumulation of karyopherin α6, facilitating its interaction with cargo molecules and subsequent nuclear import processes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Activates karyopherin α6 by modulating the pH-dependent processes within endosomes, which affect the trafficking of karyopherin α6 and its cargo molecules. By altering endosomal pH, chloroquine promotes the efficient release and nuclear translocation of karyopherin α6-bound cargo, facilitating nuclear import events. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Indirectly activates karyopherin α6 by inhibiting the activity of Hsp90, a chaperone protein that stabilizes karyopherin α6 and regulates its nuclear import function. By inhibiting Hsp90, geldanamycin promotes the destabilization and subsequent activation of karyopherin α6, facilitating its nuclear import capacity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates karyopherin α6 by modulating the activity of adenylate cyclase and cAMP signaling pathways, which regulate the phosphorylation status and nuclear translocation of karyopherin α6. By activating these pathways, forskolin promotes the phosphorylation-dependent activation and nuclear import capacity of karyopherin α6, facilitating efficient nuclear import processes. | ||||||