Kaiso Activateurs

Les activateurs Kaiso courants comprennent notamment la 5-Aza-2′-Deoxycytidine CAS 2353-33-5, la trichostatine A CAS 58880-19-6, l'acide hydroxamique Suberoylanilide CAS 149647-78-9, l'acide valproïque CAS 99-66-1 et le butyrate de sodium CAS 156-54-7.

The chemical class of Kaiso activators includes a variety of compounds that indirectly influence the activity of Kaiso, a transcription factor involved in the regulation of gene expression. These compounds mainly exert their effects by modulating epigenetic modifications and chromatin structure, thereby influencing Kaiso's interaction with DNA and histones. The main members of this class, such as 5-Aza-2'-deoxycytidine, trichostatin A, vorinostat and valproic acid, act primarily as inhibitors of DNA methyltransferases and histone deacetylases. Their actions lead to changes in DNA methylation and histone acetylation, respectively, which can affect Kaiso's ability to bind to DNA and alter its transcriptional regulatory functions. For example, reduction of DNA methylation by 5-Aza-2'-deoxycytidine may decrease Kaiso binding to methylated DNA, which may alter the expression of Kaiso-regulated genes.

Other compounds in this class, including curcumin, resveratrol, genistein and epigallocatechin gallate, influence Kaiso activity via various signaling pathways and epigenetic mechanisms. These compounds modulate factors such as sirtuin activity, tyrosine kinase signaling and other pathways, leading to changes in chromatin structure and gene expression profiles. This indirect modulation of Kaiso function reflects the complex network of cell signalling and gene regulation in which Kaiso operates.