KA1 Activators
KA1 Activators are a diverse group of chemical compounds that amplify the functional activity of KA1 through distinct but converging mechanisms, primarily by interacting with the AMPA receptor complexes that KA1 is a part of. Cyclothiazide, by preventing AMPA receptor desensitization, ensures sustained excitatory signaling, thus amplifying KA1's role in synaptic transmission. Similarly, Aniracetam and S-18986 both act as positive allosteric modulators, enhancing the receptor's response to glutamate and, by extension, the activity of KA1 through increased ion conductance. Nooglutyl and Piracetam, although their precise mechanisms are not fully elucidated, are believed to interact with the AMPA receptor, leading to enhanced neuronal communication that would include KA1's contributions. Sunifiram and PEPA, by positively modulating AMPA receptors, strengthen excitatory synaptic responses, reinforcing the neuronal activities wherein KA1 is involved.
Further, agents like CX-516 and LY392098 potentiate AMPA receptor function, which would enhance the activity of KA1 by facilitating excitatory neurotransmission. IEM-1460, while primarily acting to inhibit non-selective cation channels, indirectly augments KA1's activity by shifting the balance of ionic currents toward those mediated by AMPA receptors inclusive of KA1. IDRA-21 enhances synaptic transmission by modulating AMPA receptors, thereby amplifying the activity of KA1. Lastly, Farampator promotes cognitive functions by potentiating the AMPA receptor activity, which includes the KA1 subunit, ensuring that the neuron's response to excitatory stimuli is heightened.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a direct activator of protein kinase C (PKC) which can then phosphorylate KA1, enhancing its activity by promoting its active conformation or facilitating its interaction with downstream signaling components. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which activate PKA. PKA phosphorylation can lead to the activation of KA1 by promoting its interaction with cAMP response element-binding protein (CREB) or other transcription factors that regulate KA1 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium/calmodulin-dependent protein kinases (CaMKs) which could phosphorylate and activate KA1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a tyrosine kinase inhibitor that may enhance KA1 activity by reducing competitive phosphorylation events, thereby allowing for KA1's preferential activation or interaction with its substrates. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, can lead to the activation of KA1 by altering the PI3K/AKT pathway, potentially reducing negative feedback loops that inhibit KA1 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which may result in the activation of KA1 through the redirection of signaling flux from p38 MAPK to pathways that directly activate KA1. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate can activate sphingosine kinase, which in turn may enhance KA1 activity through sphingolipid signaling pathways that regulate cellular processes such as proliferation and survival. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the SERCA pump, potentially activating KA1 through calcium-dependent signaling mechanisms. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that could indirectly activate KA1 by inhibiting kinases that phosphorylate inhibitory sites on KA1 or its regulatory proteins. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059, an inhibitor of MEK, which is upstream of ERK, might lead to the activation of KA1 by attenuating ERK activity, thereby allowing signaling pathways that activate KA1 to prevail. | ||||||