Junctional SR Marker Activators
unctional SR Marker Activators encompass a suite of chemical compounds that enhance the functional activity of the Junctional SR Marker by manipulating calcium signaling in muscle cells. Ryanodine and 4-Chloro-m-cresol directly bind to and activate ryanodine receptors on the sarcoplasmic reticulum, resulting in augmented calcium release which is fundamental to the Junctional SR Marker's role in calcium signaling. Similarly, Caffeine and Dantrolene modulate these receptors, with caffeine enhancing release and dantrolene affecting the receptors in a way that leads to an increase in stored calcium that upon release, can activate the Junctional SR Marker.
Thapsigargin and Cyclopiazonic Acid both inhibit the SERCA pump, which is responsible for sequestering calcium within the SR, thereby increasing cytosolic calcium concentration and potentially enhancing the signaling activity of the Junctional SR Marker. Tetracaine and Carvedilol interact with RyR channels, altering calcium release dynamics and indirectly influencing the activity of the Junctional SR Marker. Lastly, Xestospongin C and BTP2 target different aspects of calcium signaling; Xestospongin C inhibits IP3 receptors which can lead to increased calcium release from the SR, while BTP2's inhibition of SOCE pathways can modulate calcium influx and thus, indirectly influence the Junctional SR Marker.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine acts as a RyR activator, increasing calcium release from the SR, which could enhance the functional activity of the Junctional SR Marker involved in calcium-dependent signaling pathways within muscle cells. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene selectively blocks RyR1, which can lead to an accumulation of calcium in the SR. Subsequent release can indirectly enhance the functional activity of the Junctional SR Marker associated with calcium bursts. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
CGP-37157 inhibits the mitochondrial sodium-calcium exchanger, which can lead to increased cytosolic calcium levels and indirectly enhance the functional activity of the Junctional SR Marker by boosting calcium signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, facilitating the transport of calcium across cellular membranes, which could enhance the functional activity of the Junctional SR Marker by increasing intracellular calcium concentration. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
This compound is a SERCA inhibitor, resulting in elevated cytosolic calcium levels, thereby enhancing the functional activity of the Junctional SR Marker indirectly through increased calcium signaling. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $124.00 $240.00 $530.00 $999.00 $1530.00 | 2 | |
Carvedilol has been shown to interact with RyR2, potentially altering calcium dynamics in the SR and indirectly enhancing the functional activity of the Junctional SR Marker. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
Xestospongin C is an inhibitor of the inositol trisphosphate receptor (IP3R), which may lead to enhanced calcium release from internal stores and indirectly increase the activity of the Junctional SR Marker. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $189.00 | 9 | |
BTP2 is an inhibitor of store-operated calcium entry (SOCE), which can modulate intracellular calcium levels and indirectly enhance the functional activity of the Junctional SR Marker. | ||||||