Junctional SR Marker Inhibitors
unctional SR Marker inhibitors are a set of chemical compounds that can potentially decrease the functional activity of Junctional SR Marker through specific signaling pathways or biological processes that it is directly involved in. These inhibitors target various components of the cellular calcium signaling system, which is known to be directly involved in the function of Junctional SR Marker. They operate through multiple mechanisms, including the inhibition of ryanodine receptors, the inhibition of the SERCA pump, the antagonism of IP3 receptors, the inhibition of store-operated calcium channels, and the inhibition of voltage-gated calcium channels.
Ryanodine and Dantrolene inhibit the ryanodine receptor, preventing the release of calcium from the sarcoplasmic reticulum. Thapsigargin inhibits the SERCA pump, preventing the reuptake of calcium into the sarcoplasmic reticulum. 2-APB and Xestospongin C act as IP3 receptor antagonists, disrupting IP3-mediated calcium release. BTP2 and SKF-96365 inhibit store-operated calcium channels and receptor-mediated calcium entry respectively, both of which disrupt calcium influx into the cell. Tetracaine and Lidocaine are local anesthetics that inhibit voltage-gated sodium channels, indirectly affecting calcium signaling. Finally, Nifedipine and Verapamil are calcium channel blockers that inhibit L-type calcium channels, preventing calcium influx and thereby disrupting calcium signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine interferes with the ryanodine receptor, a calcium-release channel located in the sarcoplasmic reticulum. By altering the function of this receptor, ryanodine can disrupt calcium signaling which is necessary for the function of Junctional SR Marker. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), preventing the reuptake of calcium into the sarcoplasmic reticulum, disrupting calcium signaling and thereby potentially inhibiting the function of Junctional SR Marker. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine is a local anesthetic that blocks voltage-gated sodium channels, which can indirectly affect calcium signaling in the cell and potentially inhibit the function of Junctional SR Marker. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is an IP3 receptor antagonist, which can disrupt calcium signaling and potentially inhibit Junctional SR Marker. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry, which can disrupt calcium signaling and potentially inhibit the function of Junctional SR Marker. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is a general inhibitor of calcium channels which can disrupt calcium signaling and potentially inhibit the function of Junctional SR Marker. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine is a local anesthetic that inhibits voltage-gated sodium channels, which can indirectly affect calcium signaling and potentially inhibit the function of Junctional SR Marker. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that can inhibit L-type calcium channels, disrupting calcium signaling and potentially inhibit the function of Junctional SR Marker. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that inhibits L-type calcium channels, disrupting calcium signaling and potentially inhibit the function of Junctional SR Marker. | ||||||