ITPK1 Activators
ITPK1 Activators encompasses a range of compounds that indirectly influence the activity of Inositol-trisphosphate 3-kinase A (ITPK1). ITPK1 is a critical enzyme in the phosphoinositide signaling pathway, responsible for the phosphorylation of inositol trisphosphate (IP3) into inositol tetrakisphosphate (IP4). The activation or modulation of ITPK1 is not directly targeted by these chemicals; instead, they affect the enzyme's activity by altering the levels of its substrates or modulating related signaling pathways.
Compounds like Lithium Carbonate can impact the metabolism of inositol phosphates, which can indirectly influence the availability of ITPK1's substrates. By altering the concentration of IP3, these compounds can modulate the activity of ITPK1. Similarly, U73122, and the calcium chelator BAPTA-AM, can indirectly affect ITPK1 by changing the dynamics of calcium and inositol phosphate signaling within the cell. Calcium ionophores, like ionomycin, including SK&F 96365 and Thapsigargin, play a role in altering intracellular calcium levels. Since calcium signaling is intricately linked with the phosphoinositide pathway, these modifications can indirectly affect ITPK1 activity. 2-Aminoethoxydiphenyl borate (2-APB) and Xestospongin C, also influence the pathway by altering the receptor dynamics, which could impact ITPK1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium carbonate can affect inositol monophosphatase, potentially altering inositol trisphosphate levels and indirectly influencing ITPK1 activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that can modulate calcium signaling, potentially affecting ITPK1 activity. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB affects inositol trisphosphate receptors, potentially influencing the signaling pathways involving ITPK1. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SK&F 96365 inhibits receptor-mediated calcium entry, which could indirectly influence ITPK1 activity. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
Xestospongin C is an inhibitor of the inositol trisphosphate receptor, potentially affecting ITPK1-related signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis, indirectly affecting pathways involving ITPK1. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid is a calcium ATPase inhibitor, potentially affecting ITPK1 activity indirectly. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin can bind to phosphoinositides, potentially influencing ITPK1 signaling pathways. | ||||||