Date published: 2026-4-19

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IRE1 α Antibodies

Santa Cruz Biotechnology offers a broad range of IRE1 α monoclonal antibodies for investigating cellular stress responses. IRE1 α monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IRE1 α is a key component of the unfolded protein response (UPR), playing a vital role in maintaining cellular homeostasis under stress conditions. As a crucial regulator of gene expression and apoptosis, IRE1 α is essential for cell survival and function. Dysregulation of IRE1 α has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its importance as a therapeutic target. Understanding IRE1 α's role in cellular stress responses can provide valuable insights into disease mechanisms and potential treatments. Research utilizing IRE1 α monoclonal antibodies has revealed significant connections between cellular stress pathways and various pathological conditions. Investigating IRE1 α functions continues to advance our knowledge of stress-related cellular processes. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of cellular stress responses and their impact on human health.

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IRE1 α Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

IRE1α Antibody (B-12)

sc-390960mouse IgG1 κ371-560 (h)WB, IP, IF, ELISAm, r, h
68
(27)

IRE1α Antibody (YB-17)

sc-100772mouse IgG2a κ401-500 (h)WB, IP, IF, ELISAh
1
(3)

IRE1 α CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRE1α CRISPR/Cas9 KO Plasmid (h)

sc-400576hGene KnockoutGFP
4
(3)

IRE1α HDR Plasmid (h)

sc-400576-HDRhHomology Directed RepairPuromycin
4
(3)

IRE1α Double Nickase Plasmid (h)

sc-400576-NIChGene KnockoutPuromycin
4
(3)

IRE1α Double Nickase Plasmid (h2)

sc-400576-NIC-2hGene KnockoutPuromycin
4
(3)

IRE1α CRISPR/Cas9 KO Plasmid (m)

sc-429758mGene KnockoutGFP
5
(0)

IRE1α HDR Plasmid (m)

sc-429758-HDRmHomology Directed RepairPuromycin
5
(0)

IRE1α Double Nickase Plasmid (m)

sc-429758-NICmGene KnockoutPuromycin
5
(0)

IRE1α Double Nickase Plasmid (m2)

sc-429758-NIC-2mGene KnockoutPuromycin
5
(0)

IRE1 α CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRE1α CRISPR Activation Plasmid (h)

sc-400576-ACThGene ActivationPuro, Blast, Hygro
4
(3)

IRE1α Lentiviral Activation Particles (h)

sc-400576-LAChGene ActivationPuro, Blast, Hygro
4
(3)

IRE1 α siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRE1α siRNA (h)

sc-40705hGene SilencingN/A
41
(0)

IRE1α shRNA Plasmid (h)

sc-40705-SHhGene SilencingPuromycin
41
(0)

IRE1α shRNA (h) Lentiviral Particles

sc-40705-VhGene SilencingPuromycin
41
(0)

IRE1α siRNA (m)

sc-40706mGene SilencingN/A
6
(0)

IRE1α shRNA Plasmid (m)

sc-40706-SHmGene SilencingPuromycin
6
(0)

IRE1α shRNA (m) Lentiviral Particles

sc-40706-VmGene SilencingPuromycin
6
(0)

IRE1α siRNA (r)

sc-270028rGene SilencingN/A
3
(0)

IRE1α shRNA Plasmid (r)

sc-270028-SHrGene SilencingPuromycin
3
(0)

IRE1α shRNA (r) Lentiviral Particles

sc-270028-VrGene SilencingPuromycin
3
(0)